Author Topic: Dopamine, Blue Lotus, MAOI and Kambo  (Read 28100 times)

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Offline Jox

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Dopamine, Blue Lotus, MAOI and Kambo
« on: November 21, 2012, 12:22:50 PM »
Hi all,

my thread went in a different direction but very interesting one. I wonder if it could be explored in a new thread.

in this thread by the end the discussion I am interested starts:
http://kambo.me/smf/index.php?topic=153.0

One of my main porblems with CFS, is the sleep. After physical stress, my body doesn't sleep. Nothing made it better, yet just two weeks ago something happened:

I did Kambo on Sunday and then Caapi 100mg brew on Wednesday. For a week I could take naps. For me that hasn't happened in 25 years.

I got confused, didn't know what caused it, it was not Kambo, because I did it for 6 months and it didn't produce sleep. If I do Caapi alone it doesn't produce sleep either.

Yet in a thread, I mentioned Peaceful Warrior, talks about blue lotus and dopamine interruptions.

Yet on Wiki I found out:

Dopamine is directly broken down into inactive metabolites by two enzymes, monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). It is equally metabolized by the two respective isoforms of MAO, MAO-A and MAO-B.

So in other words, MAOI, or Caapi, INCREASES the dopamine (?).

then on :
http://library.thinkquest.org/13561/english/physical.html

Dopamine is located adjacent to where Endorphin is released in the brain. And so there is a link, so that when Dopamine function declines, so does Endorphin function. Endorphins regulate pain. And so, pain increases when stress causes the Dopamine function to fail.

What would be connection with Kambo and Caapi to cause the sleep?

It seems that Blue Lotus does exactly the opposite, right? it suppresses the dopamine.

Any ideas?

I am just brain storming, but I am onto something very important for my health, so I guess I would have to practice with all this plants and Kambo to see what will do it.

Jox


Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #1 on: November 21, 2012, 01:33:38 PM »
this is a very good post good job man!

i have to go out right now but later i will post a bunch of stuff this brings to mind, for now ill post these few things:

"It seems that Blue Lotus does exactly the opposite, right? it suppresses the dopamine."

blue lotus shuts down dopamine for a few hours strongly then it comes back up even stronger then it fell, and after all this wears off you get long term improvement (increase) in dopamine function.

"Dopamine is directly broken down into inactive metabolites by two enzymes, monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). It is equally metabolized by the two respective isoforms of MAO, MAO-A and MAO-B.

So in other words, MAOI, or Caapi, INCREASES the dopamine (?)."

"inactive metabolites"
this is false, they are screening activity based on a very small category of effects.

mao B inhibitors increase dopamine more than mao A inhibitors, Wikipedia has non-complete information.

mao A inhibitors also increase serotonin, witch will suppress dopamine slightly(temporary), dopamine has many more metabolites than these sites are aware of.

it can be made into an acid, and an alcohol, now if you can find out what enzyme transforms dopamine into an alcohol, you can use the ALDH + piperidine method i made a thread about here, and you would have dopamine recycle itself over and over for potentially hours/days or more at a time with a single use. 


now... if you really want to sleep, put on a nicotine patch wait 15-30 minutes and take a puff of a cigaret and lay down and go for a nap, you will have the most lucid terrifying dreams of your entire life and when you wake up you will be driven to stay awake in desperate attempt to avoid the nightmares. its not important you do this this is a lead in:

now when you feel terror(regardless of dreaming or awake), nightmares this produces the chemical that leads to quality rest, you get traumatized and eventually transcend the traumatisation by morning, this happens every night inside the shell of dream induced amnesia, so as that the benefits of facing the gorgon can be attained without it disrupting your slow plodding along life routine.


from a glance what it looks like there are a few possibilities:

kambo agonized endorphin (and serotonin by connection) short term, when this wore off around wednesday it lead to reduced serotonin effect(withdrawal), giving way to more room for dopamine to flourish(dopamine=yang, serotonin=yin when one is down it leads the other up), the caapi would increase the amount of dopamine because it likely inhibits MAO B a bit on top of MAO A. the caapi also has effects on improving dream recall similar to how cannabis and rodila roaea does, and a few other compounds like huperzine A, keep in mind always remembering your dreams = improved quality of physical and mental rest, the more you remember them the stronger this should be, you could probably use caapi every 3 or more days for dream recall the way it does so has tolerance that lasts around 3 days.


i have a few tests for you, wait at least 3-7 days after not taking caapi or any mao inhibitor A or B then eat a full can of beans to yourself, see if it makes you able to sleep, or sleepy in the way YOU need to be to get restful sleep, then report the results.

depending on how this effects you we may be able to work out an extremely low cost means of getting you good, long, physically and mentally restful sleep.

Offline Jox

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #2 on: November 21, 2012, 06:46:12 PM »
Hey Peacefull Warrior,

I read your posts on this forum, and looked at your links. This sounds like super complicated. Do you make your own extractions?

Or better it seems I need to enhance the dopamine and endorphine levels, especially after gym time. What should I do then.

Regarding the test, I just had beans, and didn't have Caapi in a week, and nothing happened.

Yet I don't have Caapi right now, it will come any moment, then I would do it with Kambo to see if I can get back to my naps, and eventually get to sleep naturally.

But again, do you produce yourself all these things in alcohol and oils, I am kind of blown away...

Jox

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #3 on: November 21, 2012, 09:27:26 PM »
we need to determine if dopamine alone or serotonin alone will induce the easy nap state your looking for.

the cat is now OUT OF THE BAG:

look at attached image and read pdf.


actually most of the stuff in that thread is very rudamentary, if you take the time to understand a little bit of it it becomes extremely eye opening about EVERYTHING you do or eat, and how they interact with one another, everything is a variable alone and more so for every other thing in diet, im getting precognitive deja vu of having made this post in a dream before MEANING this information about how foods interact with one another (beyond what most doctors/nutritionists understand) is vitally important to one of the readers, so in the coming days i will flesh out this ifnromation grreatly, i have either had a dream of sharing this information in the past, or in the future the sharing of this information becomes greatly usefull, whenever your in the middle of doing ANYTHING and you remember a dream THINK about what you were doing when it happened, what foods you ate recently, what position you were sitting in/standing, what time it is, what you were thinking about, what you were intending on doing next, these are important to precipitating precognitory dreams and waking precognitive flashes, its usually you lived the moment in a drream or your future self is intentionall or unintentionally sending emtions related to the events consequences back to your present self, so as to steer you towards the path of least resistence.

when you lived the moment in a past dream, their are endless possabilites, a few include, you lived it in a past life and the DNA halucinations are flashing to the surface, or you lived it in a dream and the dream was caused by the infinite speed supercomputer that is the sub-concious mind taking a few small facts it is certain of (diffirent in quality from facts the concious mind takes as certain) and it takes these few certain facts and puts them into an infinite speed calculator and spits out the high probable course and gives you flasheds f the events before they occur, the way how in this post i explain 2-3 diffirent methods of achieving the same end results (in regards to precognition and such) are to be taken as a very big hint because this is an easy way to understand that these types of abilities and such are multidimensional (infinite potential means of precipitating what is qualitatively the same end results)

ideas, love, energy, light, feelings can travel through time because their vibrational frequency is EXTREMELY high wile phisical matter and others things have an extremely low vibrational frequency and are very dense so they cannot slip through the cracks.

i am pretty ill right now, i woke up with dry nasal passage and dry lungs and pit of throat, sorry about the rushed writing and crappy grammer.


ok all that shit in that other thread are not so important, if you buy natural almond extract from the grocery store and natural star anise extract, and also caffien tablets taking 20 drops (use sewing needle to poke fine hole in tin seal)  of each of the extracts and 1 caffein tablet will inhibit ALDH strongly, im pretty sure you can get caffein tablets for around 3-4$ and the other two should be 3-4$ each 

if you dont want to spend 5-10$ on L-lysine tablets you can just use black pepepr, all you have to do is put 1 tablespoon of it in a cofee filter and twist the top shut and seal it with a twist tie, boil water pour water into mug with the home made teabag in it (you must not ingest the solids for this to work) this will likely be very spicey you could use it for noodles or soup to help drink it all, L-lysine will turn into piperidine 1 hour after ingestion, black pepper tea contains piperidine ready to go as is

wondering what the purpose of all this complicated seeming stuff is?

well.....  keep the lid on this as best you can, my friend who partakes in cannabis, makes hash from his cannabis, and cooks it into food, and then he takes all these inhibitors as preparation with the right timings and the he eats the cannabis laced foods, this individual gets the same cannabis high one would get for a few hours, but in this way it lasts for about a week straight, YES THAT IS NOT AN EXAGGERATION small tiny amounts of cannabis he uses, like no more than 5-10$ worth, and he stays high for over a week at a time from a single dose when properly prepped.

timing goes like this:
hh:mm
00:00 L-lysine 1-2 gram with cup water (or wait till 00:15 and use pepper tea without solids instead of L-lysine)
00:45 20 drops each star anise extract and almond extract (both non artificial) and a 100mg caffein tablet with tiny sip water
01:00 ingest desired compound
01:15 be ready, this is not for the beginners, regardless of compound used

if you want a shorter experience that is more visual and less potent use lecithin in place of L-lysine or pepper tea this is a very good idea for beginners in this type of experience, it lasts dramatically shorter and is much easier to get used to before jumping into a multi day experience.

its actually quite entertaining to read over this now before hitting post and seeing all the slurred typing from how sick i am, lol not worth the effort to clean up.



the attachments are to large i will post the link to the torrent of the PDF containing the image and the related information

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #4 on: November 21, 2012, 09:52:56 PM »
this is the book here (http://www.amazon.com/Auricular-Acupuncture-Addiction-Mechanisms-Methodology/dp/0443068852?tag=duckduckgo-d-20)

the maker is a greedy ugly horrible person (: who would take something so powerful that costs 0$ to copy (capable of starting a paradigm shift) and charge money for it ? what a nasty fucker.

i have a copy of this i *purchased* my FRIEND downloaded it from a torrent i am having trouble finding the torrent my FRIEND found it on.

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #5 on: November 21, 2012, 10:02:08 PM »
alright fuck the creator of this book trapped spiraling in greed forever, (http://herbs.maxforum.org/2012/08/08/exploring-of-the-chemical-basis-with-witch-eos-bal/) half way down that page is a blue table showing the relationship between yin, yang, and body chemicals

DO NOT save any image from that 2 page thread, instead use control + print screen, then open ms paint and go control + V  then save the file, this sidesteps the viruses that appear to be on that page and the images in it.

Offline Kambogahuasca Panacea

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #6 on: November 22, 2012, 12:20:34 AM »
PW,
Changing the topic a bit but still somewhat on hand...

Is it your understanding that Bioperine/Piperine would potentiate Ayahuasca and/or Iboga?

My lord every time you post it is like a brand new revelation which rattles my previous conceptions.  Makes the Nexus seem like elementary school. 

Blam

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #7 on: November 22, 2012, 01:53:27 AM »
in my personal opinion the nexus has some very nice data, and were pretty well the first place to introduce me to many plant teachers, i thank all who partook in such a thing coming to fruition.

I WILL LEAVE MY PERSONAL OPINION OF THEIR INTENTIONS AT THAT if you really need details pm me, i would rather avoid making myself a target of unnamed individuals. 

and i THOROUGHLY DISPROVE of 69ron, and many of his methods, wile i appreciate his contributions (intentional and otherwise) to the advancement of science (:

"Is it your understanding that Bioperine/Piperine would potentiate Ayahuasca and/or Iboga?"

yes the procedure is different though (and it is more safe) DO ME A FAVOR AND DO NOT TRY THIS UNTIL TOMORROW WHEN I FULLY EXPLAIN HOW TO INDUCE MAO A AND OR B

what your looking for is piperidine made from putting black pepper into a coffee filter and sealing it with a twist tie and pouring boiling water into a cup with this teabag and i would imagine within 15 minutes it should contain a fair amount of piperidine this is different from the compounds you refer to "Bioperine/Piperine", i think piperidine may also be made from taking the same kind of coffee filter tea bag and putting it in 99% IPA rubbing alcohol (with ZERO denaturalants) and shaking daily for 1-2 weeks then evaporating the IPA (i think in the fridge is best) and this should yield piperidine crystals (i could be wrong this could be the method of producing the compounds you are referring to).

from what i recall:
piperidine = NOT the solids
piperine = YES the solids

piperidine is the one you want for cycling.

now. KP because you are a mighty warrior i have no fear helping you pry your left hand off the lid of the box (:

i cannot speak of iboga (i will research the chemical structure of it and its metabolites tomorrow possibly and get back to you)

but yes if you take pepper tea filtered of solids 1 hour and again 5 minutes before ayahuasca you can produce a WEEK OR MORE long ayahuasca journey this WILL NOT be with the gentle carrying over into the next couple days, this will be terrifying and HORRORS THAT CANNOT BE THOUGHT UP.  it takes more than black pepper tea filtered of solids, it is very late at night i promise to finish filling this in first thing tomorrow, you could use the method i posted:

"
timing goes like this:
hh:mm
00:00 L-lysine 1-2 gram with cup water (or wait till 00:15 and use pepper tea without solids instead of L-lysine)
00:45 20 drops each star anise extract and almond extract (both non artificial) and a 100mg caffeine tablet with tiny sip water
01:00 ingest desired compound
01:15 be ready, this is not for the beginners, regardless of compound used

if you want a shorter experience that is more visual and less potent use lecithin in place of L-lysine or pepper tea this is a very good idea for beginners in this type of experience, it lasts dramatically shorter and is much easier to get used to before jumping into a multi day experience."


also if your using aya you can take the caffeine tablet and crack into into 1/4th and only take a quarter of it, or remove it altogether and use an extra 10-20 drops of the 2 extracts each. i am not entirely certain of how strongly you may feel stimulated combining caffeine with aya even if beforehand. it may be dangerous is why i suggest against. i have many MAOI but not actual aya vine to test the safety personally, i think somebody at herbsmax may have tested it beforehand and got extreme blood pressure.

please try this part in bold before you use try it with pepper tea or L-lysine  PLEASE



now it is possible to use this method to do a smaller dose and have it last for very long with a much smaller potency, and when you get comfortable with small potency long lasting versions, then i would advise you very gently bump the dose ever so slightly.

mannnn KPPPPPPPPPPP my man..   please go OK that thread when you get the chance, try not to read it all at once LOLLLLLLLLLL (: (: (:

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #8 on: November 22, 2012, 12:31:55 PM »
as far as i know you would not need a MAO a or b inducer to get this working for caapi, you just need to abstain from using caapi for around 3 days then before you dose it follow the procedure i detailed.

i am not entirely certain this will work for caapi, first off, you should search google and duckduckgo for studies regarding what enzymes metabolize the actives in caapi: harmaline, harmine, tetrahydroharmine i probably have the spellings wrong and i might have put in the wrong ones but you guys get the idea anyway, then when you know the enzymes responsible for the metabolism of those compounds you can see if any of them are turned into alcohols at ANY STAGE in the metabolism, then we can get the ball rolling.

now we can side step everything if you are not afraid to smoke caapi and an ALDH inhibitor (:

ALSO a glance on wiki i found Harmalol, and Harmol this is an alcohol i am CERTAIN you can cycle this compound, it is in syrian rue and probably caapi.

there is also Harmanamide, their is a high likelihood this could be cycled.

this is how you cut corners with this method, if you cannot turn the actives and their metabolites in alcohols or aldehydes then use their DOWNSTREAM products (what they make the body release) and turn those compounds into alcohols or aldehydes, i am fairly certain this was why my first salvia experience lasted for 3 days when i took it with ALDH inhibitors because i am fairly sure i made the piperidine metabolite of dynorphin.

however if you wish to use this procedure for ayahuasca including dmt, then the procedure would be slightly different if anyone wishes to try the procedure with dmt then post asking me and i will fully explain what you need to do, because it is different then what i have posted here.

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #9 on: November 22, 2012, 12:57:11 PM »
the following species contain alcohol versions of beta-carbolines:

https://en.wikipedia.org/wiki/Shepherdia_canadensis

https://en.wikipedia.org/wiki/Shepherdia_argentea

https://en.wikipedia.org/wiki/Apocynum_cannabinum

syrian rue does as well, i would imagine caapi does as well.

remember the alcohol versions of these compounds are the second most potent of the well known beta-carbolines, use micro doses.




Offline Jox

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #10 on: November 22, 2012, 03:50:35 PM »

My lord every time you post it is like a brand new revelation which rattles my previous conceptions.  Makes the Nexus seem like elementary school. 


Hey Kambogahuasca Panacea, I am cracking up on this.... I felt the same way. I was reading the links Peacefull Warrior put, and it felt like phd in molecular biology, which is my family business( my mother, and 3 cousins), (not me of course).  And I just wonder if they could make any sense of it... or its just US....lol...

Jox

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #11 on: November 22, 2012, 06:21:32 PM »
KP OR OTHER MOD PLEASE APPROVE THAT THREAD (: (: (:

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #12 on: November 22, 2012, 06:52:38 PM »
Of course approved, thanks for asking.  If you want to be a moderator or even administrator Peaceful Warrior let me know.  Normally this would be for PM but I wanted to be public about my respect towards you.

Is this for the DMT potentiation?  That certainly intrigues me, especially for Changa.  I'm still trying to wrap my mind around your posts and the overall non MAOI inhibitors and equally inspired by applying essential oils to the burns/non burns. 

In the future I want to make more catogarized threads out of the posts you have made. 

For real if you wanted to run the show here I think it would serve us all, maybe the entire entheogenic community at large.

Offline peacefull warrior

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #13 on: November 22, 2012, 07:19:34 PM »
if you could make it so that i can make threads without waiting for approval and still rank me below yourself and the other long standing members here i would appreciate it more (:

i fully respect and endorse you or any other chopping my posts up and redepositing them in more categorized easily digestible streamlined sections/threads whatnot (i have made quite the mess here and in many other posts lol)

i will now step by step explain the science behind ALDH cycling in this next post i will post it in that thread i made about it.

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Re: Dopamine, Blue Lotus, MAOI and Kambo
« Reply #14 on: November 22, 2012, 08:56:59 PM »
OK, sounds good, I guess I didn't realize the permission issue.  I'll try to figure that out.  Unfortunately the web master is a very busy person, leaving me to the task and I have had to learn this stuff little by little. 

Can you tell me which it needs your permission on?

I don't think you make a mess and I only wanted to make new threads from some of your infos while keeping all of your threads in their perfect form as well.  Certainly all just my opinions though, I have no complaints whatsoever.  I am a voluntariast so as little control here as possible I think will lead to the most growth overall.