The Ovientvine (Sinomenium Acutum) Compendium Thread

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Ovientvine (Sinomenium Acutum)

FYI "Caulis sinomenii" / "SC" is a term for the crude herb, usually the dry vine cut into slices.

SIN is one of the major active alkaloids isolated from Sinomenium acutum and its hydrochloride in the form of tablet (Zhengqing Fengtongning, ZQFTN) listed into the Chinese Pharmacopeia has been used for years. Since SIN was first purified by Ishiwari in the 1920s [11], a vast number of pharmacological and clinical studies performed in China and Japan have demonstrated that SIN has a broad spectrum of pharmacological effects including anti-inflammatory effect [12], [13], immunoregulatory properties [14], [15], [16], as well as sedative and analgesic actions due to its chemical structure similar to morphine [17], [18]. It also shows great efficacy in antioxidation [19], [20], cardioprotection [21], [22], neuroprotection [23], [24], hepatoprotection [25], [26] and antitumor activity [27].

sinomenine eliminates established Morphine conditioned place preference. It also interferes with multiple molecular mechanisms of opioid tolerance and dependence, like cAMP increases and intracellular calcium increase. The herb sinomenine is derived from was considered a cure for morphine dependency in it's native region.

https://europepmc.org/article/PMC/6225372

Sinomenine is an alkaloid isolated from the Sinomenium acutum plant, it is a blocker of NF-κB activation and an activator of the μ-opioid receptor, it also inhibits mast cell degranulation and histamine release. Sinomenine is also known to potentiate renewal of human embryonic stem cells.

Sinomenine, otherwise known as Cucoline is an alkaloid found in the Sinomenium acutum climbing plant, native to Asia. The plant has been used in traditional medicine as a herbal remedy often to treat age related joint conditions. It’s medicinal properties are likely a result of its rich source of Sinomenine.

https://metabology.com/sinomenine-hcl-powder-10g

Caulis sinomenii, the crude herb, was even more effective than sinomenine at reducing contractions in morphine dependent ileum, nearly to untreated levels. Rats or maybe mice were also treated.

https://www.researchgate.net/publication/288379453_Effect_of_Caulis_Sinomenii_and_sinomenine_on_naloxone-precipitated_withdrawal_response_in_morphine-dependent_models_in_vitro_and_in_vivo

I used 5g daily on tea every morning for a week. I would often nod on my normal methadone dose or use less. Ended up relapsing on fentanyl a few days, during which I didn't use any sinomenium.

After about 5 days off I restarted, nodded off 45mg methadone. My normal daily dose was 150 in two doses. Even after not using the sinomenium fire a few days, tolerance was still way lower. Could reduce it by up to 50% if you take it every day for a while. Helped withdrawal too somewhat

Caulis Sinomenii and sinomenine can effectively inhibit naloxone-precipitated withdrawal response in morphine-dependent animal models both in vivo and in vitro.[/size]

In conclusion, we demonstrated that sinomenine exhibited protective effects against morphine dependencein vivo and in vitro through theNMDAR1/CAMKII/CREB pathway. Sinomenine-induced alterationof the function of astrocyte-derived exosomes may contribute to the antidependence effects of sinomenine in morphine dependence.

pain induced by hind paw injection of complete Freund's adjuvant (CFA) in mice, which was reversed by sinomenine administration. In the anterior cingulate cortex (ACC), a region highly associated with chronic pain processing, the upregulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors and Ca2+/calmodulin-dependent protein kinase II, total levels of GluA1, and phosphorylation of GluA1 at Ser831 (p-GluA1-Ser831) were reversed by systemically administrating sinomenine.

In the CPP test, morphine induced significant behavioral alteration, while pretreatment with sinomenine or methadone, resulted in decreased activity time in the morphine-paired compartment significantly. Morphine also increased the integral optical density value of TH- and NR2B-positive cells in the zebrafish brain, and reduced the amount of opioid receptors. However, the compound sinomenine could attenuate these effects. These findings demonstrate that sinomenine (80mg/kg) decreased the CPP effects of zebrafish induced by morphine significantly, downregulated expression of TH and NR2B, and upregulated μ-opioid (zfmor) and δ-opioid (zfdor1 and zfdor2) receptor expression in the CPP zebrafish brains.

In addition, sinomenine supplementation can suppress N-methyl-D-aspartate (NMDA) receptor-mediated Ca(2+) influx and induce gamma-aminobutyric acid type A (GABA(A)) receptor-mediated Cl(-) influx, each of which contributes to the improvement of morphine dependence & sleep disturbance.

The crude Sinomenium acutum herb is very effective. After three days of daily use of 6g brewed in water for 30 minutes I was able to quit daily fentanyl and reduce my daily methadone with no issues. Even nodding out from less than my normal doses.

Great herb, spread the word, this may be a true cure for opiate use. I will update in a few days. Be conservative with dosing, I noticed some respiratory depression when re brewing the same morning dose in the evening. Respiratory and heart failure can occur with overdose. 6g is probably the highest I would go, and that's tea, not ingesting it

https://www.reddit.com/r/DrugNerds/comments/qgjiss/sinomenine_protects_against_morphine_dependence_a/