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Kambo & Other Sacraments / A New Paradigm: Tobacco Disinformation
« on: June 24, 2014, 02:26:29 PM »
E-Cigarettes
When vaporizing cannabis or tobacco alone, minimal vapor will appear during exhalation. That which has not been absorbed by the lungs. E-Cigs use vegetable glycerin and Propylene Glycol to produce smoke. Usually with higher ratios of PG, as it is more popular.
PG is runnier than the VG variety, and is more easily absorbed by the polyfill fabric inside the cartomizer. The low density of the juice also means that gunk doesn’t build up on the heating element of your e-cigarette as fast as it does when thicker vegetable glycerin liquid is used. PG causes allergic reactions in some users. These can vary from minor reactions, like a tingling sensation in the throat, to serious irritations on various parts of the body. It also causes a stronger throat hit, more like a regular cigarette. PG-based e-juices are flavorless so produce the highest flavor intensity of the two substances. Also vapor feels warmer since it takes less time and power for PG to reach the level of vaporization. Vegetable Glycerin contains preexisting flavor and sweetness, produces more vapor, and is more natural.
Propylene Glycol and Ethylene Glycol are used to make antifreeze and de-icing solutions for cars, airplanes, and boats; to make polyester compounds; and as solvents in the paint and plastics industries. Propylene Glycol is an FDA-approved food additive "generally recognized as safe". It has no long-term history of human usage but seems to be toxic in excessively large amounts. Excessively high amounts cause Renal (kidney) failure. Correlating with the amounts consumed, Polypropylene Glycol contributes to Acidosis, an increased acidity in the blood and other body tissue. Those with cancer will want to avoid blood acidity. PG may also cause irritation and sensitivity to the eyes, skin and mucous membranes, according to the Scholar Chemistry Material Safety Data Sheet.
source: acute renal failure has been attributed to propylene glycol http://www.ncbi.nlm.nih.gov/pubmed/9214414
And the solvents can transform into something even more worrisome: carbonyls. This group includes known cancer-causing chemicals, such as formaldehyde, and suspected carcinogens, such as acetaldehyde.
Earlier this year, a study found that increasing an e-cig’s voltage from 3.2V to 4.8V while using an e-liquid with both solvents produced almost as much formaldehyde as a traditional*[additive] cigarette. While the human body produces formaldehyde as a byproduct of normal metabolic activity in the cells, it is suspected of being carcinogenic when inhaled.
The same study also found that at lower voltages, e-cigs produced up to 800 times less formaldehyde than a cigarette. While this might sound a lot safer, the size of the vapor particles and the delivery method into the lungs heavily impact the risk of disease.
Particles found in inhaled cigarette smoke have a median size of 0.3-0.5 microns. Testing has found that the e-cigarette particles have a median of 0.18-0.27 microns. About 40% of these particles can travel deep into the lungs and become embedded in the alveoli, where gas exchange occurs. Even if the particle itself isn’t toxic, the size alone places a burden on the lungs and can cause disease.
E-cigarettes deliver high levels of nanoparticles, the researchers found, which can trigger inflammation and have been linked to asthma, stroke, heart disease, and diabetes (SN: 7/18/09, p. 26). The levels “really raise concerns about heart disease and other chronic conditions where inflammation is involved,”
The mass of particles in the vapors is about 3 milligrams per cubic meter of air, he says, or about 100 times as high as the Environmental Protection Agency’s 24-hour exposure limit for levels of fine air particles. Thornburg’s group’s analyses predict that some 40 percent of these inhaled particles would deposit in the lungs’ smallest, deepest airways.
In addition to nicotine and solvents, vapors also contain chemical flavorings and food preservatives from the vaping liquid. Although they may be GRAS, or “generally recognized as safe” by FDA, Thornburg says, the designation is based on tests of the compounds when they are ingested. “No one has considered their safety when it comes to inhalation,” he says.
And e-cigarette vapors can even make dangerous germs harder to kill, Laura Crotty Alexander reported May 18 at an American Thoracic Society meeting in San Diego. A pulmonary and critical care physician and scientist with the VA San Diego Healthcare System, she exposed methicillin-resistant Staphylococcus aureus, better known as MRSA, to e-cigarette vapors.
In a lab dish, these antibiotic-resistant bacteria, which can cause pneumonia, proved harder to kill using a germ-killing protein fragment — a natural antibiotic that people’s bodies make. One reason: Germs exposed to nicotine-rich vapors secreted a thicker biofilm coating that protected them.
Crotty Alexander also allowed mice to breathe in air containing MRSA that had been exposed to e-cigarette vapors. One day later, mice getting vapor-exposed germs had three times as many bacteria growing in their lungs as did mice that got unexposed germs.
http://www.iflscience.com/health-and-medicine/studies-reveal-health-risks-e-cigarettes
https://www.sciencenews.org/article/health-risks-e-cigarettes-emerge
Worst to best
Regular commercial cigarettes>Additive-free cigarettes>electronic cigarettes>TRUE all-natural brands (Seneca's, Natives, Skydancer, Kentucky Select)> Mapacho tobacco> Organic tobacco> Organic Mapacho tobacco>homegrown organic tobacco> homegrown organic mapacho tobacco
Tree Tobacco (Nicotiana glauca) is another species of tobacco which is sometimes available. Not possessed and adulterated by corporate entities. This tobacco gives a similar buzz to n. rustica (mapacho) and was considered one of the strongest domestic tobacco species by native americans. It contains Anabasine, an analog of nicotine. Other forms of administration than smoking, however, would be ill-advised with this species; As Anabasine is more potent than nicotine and will reach toxic levels in the body faster/with lower quantities. Tree Tobacco, tho, is safe for smoking.
Raw brand rolling papers are organic, raw, unrefined, hemp paper. They are much more natural and produce less material, harshness, and carcinogens when burning. If using paper, be sure to use these.
Mapacho Tobacco aka Shamanic Tobacco, Sacred Tobacco, Tobacco Negra (Nicotiana rustica) contains up to 18x more nicotine (but freebased nicotine is not added in) and is much higher in harmalas than regular tobacco which balances the effects. Harmalas have anti-depressant effects, anti-tumor properties, and are NMDA antagonists which help prevent addictions. NMDA antagonists also resensitize cells to dopamine. So NMDA antagonists have "brain-resetting" effects.
There was a lecture online about harmalas effects as anti-tumor. I'm trying to find this.
"However, there is enough available evidence that ayahuasca’s active principles, especially DMT and harmine, have positive effects in some cell cultures used to study cancer, and in biochemical processes important in cancer treatment, both in vitro and in vivo. "
http://smo.sagepub.com/content/1/2050312113508389.full
"In conclusion, our study shows that harmine derivatives have considerable antitumor activity"
http://onlinelibrary.wiley.com/doi/10.1002/ijc.20703/full
When vaporizing cannabis or tobacco alone, minimal vapor will appear during exhalation. That which has not been absorbed by the lungs. E-Cigs use vegetable glycerin and Propylene Glycol to produce smoke. Usually with higher ratios of PG, as it is more popular.
PG is runnier than the VG variety, and is more easily absorbed by the polyfill fabric inside the cartomizer. The low density of the juice also means that gunk doesn’t build up on the heating element of your e-cigarette as fast as it does when thicker vegetable glycerin liquid is used. PG causes allergic reactions in some users. These can vary from minor reactions, like a tingling sensation in the throat, to serious irritations on various parts of the body. It also causes a stronger throat hit, more like a regular cigarette. PG-based e-juices are flavorless so produce the highest flavor intensity of the two substances. Also vapor feels warmer since it takes less time and power for PG to reach the level of vaporization. Vegetable Glycerin contains preexisting flavor and sweetness, produces more vapor, and is more natural.
Propylene Glycol and Ethylene Glycol are used to make antifreeze and de-icing solutions for cars, airplanes, and boats; to make polyester compounds; and as solvents in the paint and plastics industries. Propylene Glycol is an FDA-approved food additive "generally recognized as safe". It has no long-term history of human usage but seems to be toxic in excessively large amounts. Excessively high amounts cause Renal (kidney) failure. Correlating with the amounts consumed, Polypropylene Glycol contributes to Acidosis, an increased acidity in the blood and other body tissue. Those with cancer will want to avoid blood acidity. PG may also cause irritation and sensitivity to the eyes, skin and mucous membranes, according to the Scholar Chemistry Material Safety Data Sheet.
source: acute renal failure has been attributed to propylene glycol http://www.ncbi.nlm.nih.gov/pubmed/9214414
And the solvents can transform into something even more worrisome: carbonyls. This group includes known cancer-causing chemicals, such as formaldehyde, and suspected carcinogens, such as acetaldehyde.
Earlier this year, a study found that increasing an e-cig’s voltage from 3.2V to 4.8V while using an e-liquid with both solvents produced almost as much formaldehyde as a traditional*[additive] cigarette. While the human body produces formaldehyde as a byproduct of normal metabolic activity in the cells, it is suspected of being carcinogenic when inhaled.
The same study also found that at lower voltages, e-cigs produced up to 800 times less formaldehyde than a cigarette. While this might sound a lot safer, the size of the vapor particles and the delivery method into the lungs heavily impact the risk of disease.
Particles found in inhaled cigarette smoke have a median size of 0.3-0.5 microns. Testing has found that the e-cigarette particles have a median of 0.18-0.27 microns. About 40% of these particles can travel deep into the lungs and become embedded in the alveoli, where gas exchange occurs. Even if the particle itself isn’t toxic, the size alone places a burden on the lungs and can cause disease.
E-cigarettes deliver high levels of nanoparticles, the researchers found, which can trigger inflammation and have been linked to asthma, stroke, heart disease, and diabetes (SN: 7/18/09, p. 26). The levels “really raise concerns about heart disease and other chronic conditions where inflammation is involved,”
The mass of particles in the vapors is about 3 milligrams per cubic meter of air, he says, or about 100 times as high as the Environmental Protection Agency’s 24-hour exposure limit for levels of fine air particles. Thornburg’s group’s analyses predict that some 40 percent of these inhaled particles would deposit in the lungs’ smallest, deepest airways.
In addition to nicotine and solvents, vapors also contain chemical flavorings and food preservatives from the vaping liquid. Although they may be GRAS, or “generally recognized as safe” by FDA, Thornburg says, the designation is based on tests of the compounds when they are ingested. “No one has considered their safety when it comes to inhalation,” he says.
And e-cigarette vapors can even make dangerous germs harder to kill, Laura Crotty Alexander reported May 18 at an American Thoracic Society meeting in San Diego. A pulmonary and critical care physician and scientist with the VA San Diego Healthcare System, she exposed methicillin-resistant Staphylococcus aureus, better known as MRSA, to e-cigarette vapors.
In a lab dish, these antibiotic-resistant bacteria, which can cause pneumonia, proved harder to kill using a germ-killing protein fragment — a natural antibiotic that people’s bodies make. One reason: Germs exposed to nicotine-rich vapors secreted a thicker biofilm coating that protected them.
Crotty Alexander also allowed mice to breathe in air containing MRSA that had been exposed to e-cigarette vapors. One day later, mice getting vapor-exposed germs had three times as many bacteria growing in their lungs as did mice that got unexposed germs.
http://www.iflscience.com/health-and-medicine/studies-reveal-health-risks-e-cigarettes
https://www.sciencenews.org/article/health-risks-e-cigarettes-emerge
Worst to best
Regular commercial cigarettes>Additive-free cigarettes>electronic cigarettes>TRUE all-natural brands (Seneca's, Natives, Skydancer, Kentucky Select)> Mapacho tobacco> Organic tobacco> Organic Mapacho tobacco>homegrown organic tobacco> homegrown organic mapacho tobacco
Tree Tobacco (Nicotiana glauca) is another species of tobacco which is sometimes available. Not possessed and adulterated by corporate entities. This tobacco gives a similar buzz to n. rustica (mapacho) and was considered one of the strongest domestic tobacco species by native americans. It contains Anabasine, an analog of nicotine. Other forms of administration than smoking, however, would be ill-advised with this species; As Anabasine is more potent than nicotine and will reach toxic levels in the body faster/with lower quantities. Tree Tobacco, tho, is safe for smoking.
Raw brand rolling papers are organic, raw, unrefined, hemp paper. They are much more natural and produce less material, harshness, and carcinogens when burning. If using paper, be sure to use these.
Mapacho Tobacco aka Shamanic Tobacco, Sacred Tobacco, Tobacco Negra (Nicotiana rustica) contains up to 18x more nicotine (but freebased nicotine is not added in) and is much higher in harmalas than regular tobacco which balances the effects. Harmalas have anti-depressant effects, anti-tumor properties, and are NMDA antagonists which help prevent addictions. NMDA antagonists also resensitize cells to dopamine. So NMDA antagonists have "brain-resetting" effects.
There was a lecture online about harmalas effects as anti-tumor. I'm trying to find this.
"However, there is enough available evidence that ayahuasca’s active principles, especially DMT and harmine, have positive effects in some cell cultures used to study cancer, and in biochemical processes important in cancer treatment, both in vitro and in vivo. "
http://smo.sagepub.com/content/1/2050312113508389.full
"In conclusion, our study shows that harmine derivatives have considerable antitumor activity"
http://onlinelibrary.wiley.com/doi/10.1002/ijc.20703/full