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Topics - ―λlτεrηιτγ-

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31
Video / The Secret World of Plants (Documentary)
« on: May 02, 2019, 04:26:55 am »

32
Strong Medicine : The Secret Power of African Healing

https://youtu.be/JQkiswWChy4

33
Audio / Dr. Gary Knoll - Radio Show
« on: November 01, 2018, 02:35:32 pm »
The Gary Knoll Show -The Progressive Radio Network
https://www.youtube.com/user/PRNfm/videos

This guy might be the best doctor that's ever lived. A link to subscribe to his radio show.

35
Alkaloidology / Honokiol & Magnolol from Magnolia
« on: August 14, 2018, 05:01:49 am »
Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172228

The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

https://www.ncbi.nlm.nih.gov/pubmed/22445602

Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice

https://www.ncbi.nlm.nih.gov/pubmed/10197425

Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.

https://www.ncbi.nlm.nih.gov/pubmed/8117323

Honokiol targets mitochondria to halt cancer progression and metastasis.

https://www.ncbi.nlm.nih.gov/pubmed/27276215

University of Alabama at Birmingham found the compound - honokiol - blocked a protein that drives tumor growth in squamous cell head and neck cancers

http://www.medicalnewstoday.com/articles/295962.php

Honokiol Ameliorates Amyloidosis and Neuroinflammation and Improves Cognitive Impairment in Alzheimer's Disease Transgenic Mice.

https://www.ncbi.nlm.nih.gov/pubmed/29991481

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.
https://www.ncbi.nlm.nih.gov/pubmed/24900561

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190350

Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.

https://www.ncbi.nlm.nih.gov/pubmed/18093712

36
Diabetes / Berberine vs. Metformin
« on: July 29, 2018, 06:14:01 pm »
"Best known for its natural antibiotic activity, berberine deals a serious blow to common infectious organisms— organisms like “staph,” “strep,” Chlamydia, diphtheria, salmonella, cholera, diplococcus pneumoniae, pseudomonas, gonorrhea, candida, trichomonas, and many others.

The researchers wrote, 'Compared with metformin, berberine exhibited an identical effect in the regulation of glucose metabolism, such as HbA1c, FBG [fasting blood glucose], PBG [blood sugar after eating], fasting insulin and postprandial insulin [insulin level after eating]. In the regulation of lipid metabolism, berberine activity is better than metformin. By week 13, triglycerides and total cholesterol in the berberine group had decreased and were significantly lower than in the metformin group (P<0.05).'

Insulin resistance dropped by 45 percent!"

http://understandingtype2diabetes.com/dr-jonathan-wright-on-berberine-vs-metformin/

http://tahomaclinic.com/2011/01/berberine-diabetes/

1. Reduces inflammation
2. Improves gastrointestinal health
3. Reduces glucose production in the liver
4. Improves markers of insulin resistance
5. Lowers cholesterol
6. Lowers oxidative stress
7. Helps in losing body fat
8. Slows down aging
9. Suppresses chemical-induced carcinogenesis, clastogenesis, tumor promotion and tumor invasion
10. Exerts antiarrhythmic effects
11. Exerts anti-microbial activity against a wide range of microorganisms.
12. Exerts minor antidepressant effects, as well as work in a synergistic fashion with existing antidepressants

https://nootropix.com/berberine-extraordinary-compound/

37
Video / The Reality of Truth [Documentary]
« on: July 06, 2018, 04:38:36 pm »
The Reality Of Truth

https://youtu.be/gDG-bOIQUOw

This highly provocative documentary explores the relationship between spirituality, religion, and plant medicine. Featuring top thought leaders including Deepak Chopra, Ram Dass, Marianne Williamson, Sri Sri Ravi Shankar, and hosted by Mike “Zappy” Zapolin, the film explores how to access the true reality through plant medicine, Ayahuasca and meditation.  It includes first of its kind interviews with top spiritual gurus, celebrities, and people of all faiths, about this intriguing connection and their personal experiences with spirituality and transcendence.

Throughout history human beings have searched for gateways to spirituality that have included meditation, prayer and plant medicine. The Judeo Christian religions, Vedic traditions, and Shamanistic rituals all incorporate techniques focused on transcending the physical reality. These ancient techniques have been uncovered and are now available to society, enabling our ability to tap into our true reality and awakening.

Interviews with leading scientists validate the merging of spirituality and science.

The worldwide awareness of the film is meant to break through the “illusion of reality,” and allow viewers to move forward toward a more meaningful and peaceful future. The filmmakers are conducting interviews with today’s thought leaders from around the globe, while capturing the culture and energy of some of the most spiritual places on earth, including Peru, Rome, Maui, Costa Rica and the Maharishi University of Management in Fairfield, Iowa.

38
Quote
Alzheimer's disease is the world's most common neurodegenerative disease and a leading cause of dementia.

One feature of Alzheimer's is a buildup of protein tangles called beta amyloid plaques, in certain neurons in the brain.

A study in mice showed that a substance in olive oil can help to clear these plaques from the brain (35).

A human controlled trial showed that a mediterranean diet enriched with olive oil had favorable effects on brain function and reduced the risk of cognitive impairment (36).

39
Herb Info and Use / List of Alkaloids Identified in Kratom
« on: April 11, 2018, 10:55:46 pm »
https://www.kratomscience.com/forums/topic/list-alkaloids-identified-mitragyna-speciosa-kratom/

Kratom's constituents and their properties

Quote
Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa– Kratom leaf. Some of the alkaloids given in this list still need to be studied more specifically in order to determine their potential activity.

Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.

Akuammigine

Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.

Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.

Corynoxeine: Calcium channel blocker. < 1% of total alkaloid content found in Kratom leaf.

Corynoxine A and B: Dopamine mediating anti-locomotives. < 1% of total alkaloid content found in Kratom leaf.

Epicatechin: Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral, potential cancer preventative, alpha-amylase inhibitor. Also found in dark chocolate.

9-Hydroxycorynantheidine: Partial opioid agonist

7-hydroxymitragynine: Analgesic, antitussive, antidiarrheal; primary
psychoactive in Kratom, Roughly 2% of total alkaloid content found in Kratom leaf.

Isomitraphylline: Immunostimulant, anti-leukemic. < 1% of total alkaloid content found in Kratom leaf.

Isomitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Isopteropodine: Immunostimulant

Isorhynchophylline: Immunostimulant. < 1% of total alkaloid content found in Kratom leaf.

Isospeciofoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraciliatine: < 1% of total alkaloid content found in Kratom leaf.

Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist. Roughly 66% of total alkaloid content found in Kratom leaf.

Mitragynine oxindole B. < 1% of total alkaloid content found in Kratom leaf.

Mitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. <1% of total alkaloid contents in Kratom leaf.

Mitraversine

Paynantheine: Indole alkaloid. Smooth muscle relaxer. 8.6% to 9% of total alkaloid contents in Kratom leaf.

Rhynchophylline: Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic. < 1% of total alkaloid content found in Kratom leaf.

Speciociliatine: Weak opioid agonist. 0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom.

Speciofoline

Speciogynine: Smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of Kratom leaf.

Speciophylline: Indole alkaloid. Anti-leukemic. <1% of total alkaloid contents of Kratom leaf.

Stipulatine

Tetrahydroalstonine: Hypoglycemic, anti-adrenergic (at alpha-2)

As previously mentioned, Mitragyna speciosa Kratom alkaloid content varies quantitatively from geographical location, and from month to month, at different leaf harvest times, which has lead some teams (Shellard et al. in the 1970s) to conclude that there may be different geographical variants within the same species.
The Chelsea College Pharmacognosy Research Laboratories collected thirty samples of Kratom from Thailand, Malaysia, and Papua New Guinea between 1961 and 1970. All contained mitragynine, but also proved to have considerable variation in the alkaloid makeup. For red and green/ white leaved plants of Thailand, the most common alkaloidal profile was mitragynine, speciogynine, speciociliatine, paynantheine, traces of ajmalicine, traces of (C9) methoxy-oxindoles, and traces of other indoles.
Yet other Thai plants contained distinct alkaloidal profiles, some with many more alkaloids. In the Malay specimens, one contained mitragynine, speciofoline, and other indoles and oxindoles, while others contained mitragynine, ajmalicine, speciogynine, speciociliatine, paynantheine, traces of indoles, and (C9) methoxy-oxindoles. Specimens from Papua New Guinea contained mitragynine, speciogynine, speciociliatine, paynantheine, specionoxeine, and isospecionoxeine.
Prior to the late 1990’s, nearly all chemical studies of Kratom activity focused on mitragynine with the assumption thatmitragynine was the main active alkaloid. With 7-hydroxymitragynine now clearly identified out as the principal psychoactive alkaloid in Kratom, many elements of these studies need to be revised.

Takayama et al. also found that Thai and Malay Kratom had the alkaloids mitragynine, speciogynine, speciociliatine, paynantheine and 7-hydroxymitragynine in common. In both Thai and Malay samples, mitragynine was the most abundant alkaloid, yet it made up 66% of the total alkaloid in the Thai Kratom sample, while it made up only 12% of the alkaloids from the Malaysian sample. The Malay Kratom sample had mitragynaline and pinoresinol as major components, as well asmitralactonal, mitrasulgynine and 3,4,5,6-tetradehydromitragynine.
Working with the leaves of Malay Mitragyna Kratom plants, the Houghton and Said team found 4 new types of indole alkaloids (corynantheidaline, corynantheidalinic acid, mitragynaline and mitragynalinic acid), in very young leaves.
These new alkaloids were reported as having an unusual skeleton, with a carbon function at the C14 position (in comparison with previously known monoterpenoid indoles), but another research team, lead by Pr. Takayama, later revised the structure of the mitragynaline and corynantheidaline alkaloids, showing that there was actually no substitution on the 14 position.

The variety of alkaloids discovered in diverse Kratom samples to this day still calls for further studies and experimentation, investigating their specific activity, effects and potential applications.
Through its makeup and tradition of use, it is clear Mitragyna speciosaKratom is much more than a simple opioid-like narcotic and mild stimulant. Many of the secondary chemicals found in Mitragyna speciosa Kratom are present in small yet appreciable quantities, and their synergetic role and activity in the general pharmacology of Mitragyna speciosa Kratom is not yet fully understood, as thorough research has only just begun.


40
Application / Kambo administration - Using a straight stick / edge.
« on: January 20, 2018, 06:59:43 am »
I think the photos are self-explanatory.

42
Diabetes / Burdock
« on: December 24, 2017, 01:49:00 am »
Quote
Burdock root contains inulin, a soluble and prebiotic fiber that helps improve digestion and lower blood sugar, making it an excellent choice for people trying to naturally manage their blood sugar. In Europe, the fresh root is used for lowering blood sugar, its inulin content making it particularly suitable for diabetes. Animal studies have also shown burdock root’s ability to decrease the severity of diabetic complications, especially diabetic retinopathy. (7)

https://draxe.com/burdock-root/

43
Anti-Cancer / Wormwood
« on: December 05, 2017, 07:21:46 am »
Artemisin from Sweet Wormwood found to kill 98% of breast cancer cells:

Quote
According to recent studies, artemisinin can kill iron-enriched breast cancer cells similar to the way it kills malaria-causing parasites, making it a potential natural cancer treatment option for women with breast cancer. Cancer cells can also be rich in iron since they commonly soak it up to facilitate cell division. Researchers in a 2012 study tested samples of breast cancer cells and normal breast cells that had first been treated to maximize their iron content. The cells were then treated with a water-soluble form of artemisinin, an extract of wormwood.

Results were quite impressive. The normal cells showed little change, but within 16 hours, almost all of the cancer cells were dead and only a few normal cells were killed. Bioengineer Henry Lai believes that because a breast cancer cell contains five to 15 more receptors than normal, it absorbs iron more readily and hence is more susceptible to artemisinin’s attack.

https://draxe.com/wormwood/

https://naturalsociety.com/artemesinin-iron-causes-98-reduction-breast-cancer/

44
Quote
Recent research has proven ashwagandha is more than a stress reliever, it also protects the brain from degeneration and improves symptoms of alzheimer’s, depression, and anxiety.

One of the main reasons ashwagandha is so effective at healing the brain has to do with its powerful antioxidants that destroy free radicals that cause aging. A study published in Phytotherapy Research explains these benefits:

“Several studies have revealed that natural antioxidants, such as vitamin E, vitamin C and beta-carotene, may help in scavenging free radicals generated during the initiation and progression of this [Alzheimer’s] disease.  But we found Ashwagandha afforded lipid peroxidation inhibitory effects more potent than commercial antioxidants.”

Researchers at the National Brain Research Centre found that mice with Alzheimer’s were unable to retain what they learned, but after 20 days of supplementing with ashwagandha, this improved significantly. The results of the study found a reduction in amyloid plaques (these cause degradation of the brain).

https://draxe.com/ashwagandha-proven-to-heal-thyroid-and-adrenals/

45
A talk about medicinal mushrooms, like Lion's Mane, for brain neurology neurogenisis.
Regenerating myelin in axons of nerves. Formation of Amyloid plaques / Alzheimer's
Demyelination of the neurons, the myelin transmits the neural signals. Demyelination occurs, the outer sheaths of the neurons is interrupted by amyloid plaques which interrupt neuro-transmission.
His hypothesis that if you stack medicinal mushrooms for neurogenisis with niacin / B3, the advantage is that the niacin can help drive the neurogenic benefits of psilocybin and aromasens from lion's mane to the end of the peripheral nervous system.
https://youtu.be/mPqWstVnRjQ
Paul Stamets is a mycologist, author and advocate of bio-remediation and medicinal fungi.
25:05 - 51:50

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