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Topics - artificialintelligence

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Receptors / 5-HT2c
« on: March 25, 2017, 03:28:47 pm »
This is the flu receptor. Agonizing it reduces dopamine and norepinephrine release (not sure where but likely system-wide). Agonizing it causes the direct sensations of the flu: lack of energy and lack of wellbeing. Many entheogens agonize this receptor, directly contributing to negative sensations felt during the agonization phase, but also contributing to feelings of wellbeing during the withdrawal.

Antagonizing this receptor causes feelings of euphoria, wellbeing, and magic. It directly counteracts the sensation of the flu, and amplifies any euphoric feelings. It has been theorized that this is the "magic" receptor of MDMA. It is also possible that cocaine antagonizes this receptor, however this has not been proven and needs further investigation. It has, however, been proven that antagonization of 5-HT2c in conjuction with cocaine administration increases the reinforcement of addictive pathways.

However, when used with 5-HT1a agonists alone, it seems to provide more of an antidepressant ability to see the magic of reality again, rather than anything addictive. There is no significant withdrawal from this.

Noticeable ligands:
Kudzu (Puerarin, which is also a 5-HT1a agonist and a GABA-A antagonist)
possibly Happiness Tree

Receptors / 5-HT1a
« on: March 25, 2017, 03:06:00 pm »
This is the blissful homeostasis receptor. When it is in perfect balance, it creates a perfect antidepressant blissful enjoyment of life. It secretes mu endorphins, oxytocin, and GABA, and lightly inhibits the NMDA receptor. It produces a hot-pink visual signature.

When it is deficient, it causes crippling depression, inability to enjoy reality, and suicidal thoughts and tendencies. When it is in excess, it shuts down oxytocin and endorphin production, and releases prolactin, creating overwhelming anger. This is part of serotonin syndrome, and since most entheogens (excepting DMT) are strong 5-HT1a agonists there is considerable risk that this will play into negative effects generated. However there may be unknown mechanisms by which other receptors regulate this phenomenon.

Pure ligands:
Limonene (orange oil) (likely also agonizes 5-HT4)

Warning: there is considerable risk of depression when withdrawing from a 5-HT1a agonist. I cannot take any oil containing limonene, because of the severity of the depression that results. However, others do not seem to report the same experience, so just be on the alert. I did not always experience this, so it is possible that the body's reaction can change, possibly hinging on dietary imbalances.

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