3 Years ago, my hormones started going down for no apparent reason except a lifetime of stress sensitivity.  Now I know it may have been the breakthrough of lyme, or was it the heave hormonal supplementation I did which triggered lyme ?  Will never know.  Anyway,  I ended taking massive loads of bio-identical hormones (hormonal reaplacement therapy), and got worse. I did 3 kambo's, but I only felt a slight mental benefit, I would react physically heavily to the kambo, strung out for a full day. One year ago I did another kambo, when I was taking less hormones, but was still on the ones that affect directly the HPTA-axis (cortisol and thyroid replacement), and still didn't get a clear result.  6 Months ago I tried kambo again, being on just a few non-HPTA hormones and yes, I felt better, finally the medicine could do its work.  My shaman always told me to check my my hormones in the blood after the kambo, because I might be needing less, but my body was so messed up that I believe Kambo could not work properly.