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The Science behind the Magic (Kambo info to convince left brainers) / HIV and frog peptides
« on: January 08, 2013, 04:42:35 AM »
Hello new to this forum, I found about this forum from reading the antimicrobial properties of kambo after finding out that I was diagnosed with HIV. I know little about the disease other than what is conventially taught as prevention, so since I have not been on medication for any chronic condition all my life I searched for 'frog peptides' and hiv and found something interesting in one study that could be similarly true in the kambo medicine.
I am currently on pharmaceutical meds that work pretty well (Atripla), so far it works pretty well as far as no severe side effects. I get vivid dreams, some wooziness, and the most visible is a pale colored rash on my face and neck. I will continue my meds because it has proven to reduce the hiv viral loads to undectectable in patients. The problem is that these meds cost approx $2000/mo and I'm only getting them because I'm in a rehab housing program, with no income so the state pays for the meds for now.
The meds stop hiv from replicating and infecting the t-cells and slowly allows the immune system to rebuild. I was told by the social worker and nurse that adherence to the drug everyday is crucial for working otherwise the virus can mutate and the meds stop working which id have to go on another med.
So eventually I am considering going off the meds after much contemplation, a risky move, because of some interesting properties of these frog peptides to not only kill the HIV virus but to go in the dendritic cell where it is hiding as a Trojan horse and disrupt it, thus making it more of a possible cure if it can be done within the whole immune system.
Dermaseptin in the P. bicolor frog secretion and only one study I found referenced in one study where it penetrated the dendritic cell, but not the more powerful peptides tested that showed 80-99% inhibited the HIV virus found in the c. Interesting thing is that these two frogs look similar, both green and apparently the latter is a common 'pet frog' which makes me wonder if a 'frog peptide' stick can be easily created much like kambo is done.
Some interesting leads I found regarding all this.............
Frog Peptides Block HIV In Lab Study
http://www.sciencedaily.com/releases/2005/09/050930080923.htm
A new weapon in the battle against HIV may come from an unusual source -- a small tropical frog.
Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells
http://jvi.asm.org/content/79/18/11598.full
ABSTRACT
Topical antimicrobicides hold great promise in reducing human immunodeficiency virus (HIV) transmission. Amphibian skin provides a rich source of broad-spectrum antimicrobial peptides including some that have antiviral activity. We tested 14 peptides derived from diverse amphibian species for the capacity to inhibit HIV infection. Three peptides (caerin 1.1, caerin 1.9, and maculatin 1.1) completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells. These peptides also suppressed infection by murine leukemia virus but not by reovirus, a structurally unrelated nonenveloped virus. Preincubation with peptides prevented viral fusion to target cells and disrupted the HIV envelope. Remarkably, these amphibian peptides also were highly effective in inhibiting the transfer of HIV by dendritic cells (DCs) to T cells, even when DCs were transiently exposed to peptides 8 h after virus capture. These data suggest that amphibian-derived peptides can access DC-sequestered HIV and destroy the virus before it can be transferred to T cells. Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs.
According to the graph on the full report, Dermaseptin (also found in P. bicolor aka kambo) inhibited the virus 40% which makes me wonder if repeated kambo treatments would have cumulative effects and since this is just one study what other peptides could be at work.
Glad to see the journals like Jox has set up, and am thinking of doing something similar once I can get my blood tests as a measure of my progress, this could be towards the end of the year.
I am currently on pharmaceutical meds that work pretty well (Atripla), so far it works pretty well as far as no severe side effects. I get vivid dreams, some wooziness, and the most visible is a pale colored rash on my face and neck. I will continue my meds because it has proven to reduce the hiv viral loads to undectectable in patients. The problem is that these meds cost approx $2000/mo and I'm only getting them because I'm in a rehab housing program, with no income so the state pays for the meds for now.
The meds stop hiv from replicating and infecting the t-cells and slowly allows the immune system to rebuild. I was told by the social worker and nurse that adherence to the drug everyday is crucial for working otherwise the virus can mutate and the meds stop working which id have to go on another med.
So eventually I am considering going off the meds after much contemplation, a risky move, because of some interesting properties of these frog peptides to not only kill the HIV virus but to go in the dendritic cell where it is hiding as a Trojan horse and disrupt it, thus making it more of a possible cure if it can be done within the whole immune system.
Dermaseptin in the P. bicolor frog secretion and only one study I found referenced in one study where it penetrated the dendritic cell, but not the more powerful peptides tested that showed 80-99% inhibited the HIV virus found in the c. Interesting thing is that these two frogs look similar, both green and apparently the latter is a common 'pet frog' which makes me wonder if a 'frog peptide' stick can be easily created much like kambo is done.
Some interesting leads I found regarding all this.............
Frog Peptides Block HIV In Lab Study
http://www.sciencedaily.com/releases/2005/09/050930080923.htm
A new weapon in the battle against HIV may come from an unusual source -- a small tropical frog.
Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells
http://jvi.asm.org/content/79/18/11598.full
ABSTRACT
Topical antimicrobicides hold great promise in reducing human immunodeficiency virus (HIV) transmission. Amphibian skin provides a rich source of broad-spectrum antimicrobial peptides including some that have antiviral activity. We tested 14 peptides derived from diverse amphibian species for the capacity to inhibit HIV infection. Three peptides (caerin 1.1, caerin 1.9, and maculatin 1.1) completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells. These peptides also suppressed infection by murine leukemia virus but not by reovirus, a structurally unrelated nonenveloped virus. Preincubation with peptides prevented viral fusion to target cells and disrupted the HIV envelope. Remarkably, these amphibian peptides also were highly effective in inhibiting the transfer of HIV by dendritic cells (DCs) to T cells, even when DCs were transiently exposed to peptides 8 h after virus capture. These data suggest that amphibian-derived peptides can access DC-sequestered HIV and destroy the virus before it can be transferred to T cells. Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs.
According to the graph on the full report, Dermaseptin (also found in P. bicolor aka kambo) inhibited the virus 40% which makes me wonder if repeated kambo treatments would have cumulative effects and since this is just one study what other peptides could be at work.
Glad to see the journals like Jox has set up, and am thinking of doing something similar once I can get my blood tests as a measure of my progress, this could be towards the end of the year.