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Prevalent Cultural Conditions => Diabetes => Topic started by: ―λlτεrηιτγ- on March 15, 2016, 02:54:20 AM

Title: Harmine in the Treatment of Diabetes
Post by: ―λlτεrηιτγ- on March 15, 2016, 02:54:20 AM

Quote

In a screen of more than 100,000 potential drugs, only one, harmine, drove human insulin-producing beta cells to multiply, scientists report. "Our results provide a large body of evidence demonstrating that the harmine drug class can make human beta cells proliferate at levels that may be relevant for diabetes treatment," said the study's senior author.

References:
http://www.nature.com/nm/journal/v21/n4/full/nm.3820.html
https://www.sciencedaily.com/releases/2015/03/150309134629.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841998/

Title: Re: Harmine in the Treatment of Diabetes
Post by: ―λlτεrηιτγ- on January 11, 2017, 09:09:35 AM

The recent study is titled ‘A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication’ (http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3820.html). Researchers at the Icahn School of Medicine at Mount Sinai screened over 100,000 potential drugs, and only harmine drove human insulin-producing beta cells to multiply. This could be a significant stepping stone in the treatment of diabetes, a disease that effects hundreds of thousands of people.

A summary of the study and comments by lead research Andrew Stewart, MD, can be found at Science Daily (https://www.sciencedaily.com/releases/2015/03/150309134629.htm).

http://disinfo.com/2015/04/harmine-treatment-type-1-diabetes/