Kambo

General Category => Complementary Modalities => Topic started by: peacefull warrior on October 08, 2012, 09:25:49 PM

Title: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on October 08, 2012, 09:25:49 PM
as i dont have kambo to test and verify or un-verify the ability of its consituents to be cycled, i will start by pointing to the place ware the most information regarding this method seems to be as far as i know.

in future posts with similar compounds and similar acting compounds to kambos constituents and ideally eventually kambo itself i will document the results of tests.

documentation of past information regarding the system/theory:

(http://herbs.maxforum.org/2011/11/15/lysine-aldehyde-dehydrogenase-inhibitor-tryptophan/)

(http://herbs.maxforum.org/2012/06/30/practical-aplications-of-aldh-inhibitions-ability-/#post12)
in one post SWIM claims they got salvia to cycle for 3 days, but it was only 3 days that they were on the other side of the portal, it lasted easily 2 weeks in reality the best i can explain is 3-6 days past the threshold of "controllable" and then progressive steps into the sensation of "control" the following 11-9 days.

(http://herbs.maxforum.org/2011/05/19/ultimate-phenethylamine-potentiation/)
it would be best to read every pager and post of these threads, so as to get the complete picture of what users have found helps or hurts the system/theory

in future posts i will be quoting some of the more importantly relevant and useful posts from those and other threads from that forum regarding this system/theory.

Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on October 08, 2012, 09:56:42 PM
the best i might start with as an explanation is:

you find a compound known to be potentially capable of being broken down into an alcohol, or witch can be converted or bonded with something that is or can be broken down by a or various enzymes into an alcohol.

then you verify this becoming an alcohol by some method(s)

take 1-2g L-lysine or Lecithin and wait an hour, black pepper tea (1-2 tablespoons) filtered of solids also contains more than enough piperidine

(L-lysine is converted into piperidine in your body ~1 hour after ingestion)

(Lecithin is converted to dimethylamine by your body i don't know how long this takes probably 15 minutes-1hour or more)

some of the following have been noted by individuals who have gotten this working SOMETIMES for SOME compounds:

piperidine = more mental, longer duration, higher brain penetration and/or higher receptor affinity(possibly for different receptors or receptor sets than dimethylamine), possibly less visual

dimethylamine = more visual, shorter duration, lower/higher brain penetration and/or higher receptor affinity(possibly for different receptors or receptor sets than piperidine) possibly less mental

then you take an Aldehyde dehydrogenase inhibitor plus the necessary inducers for the enzyme(s) that break the intended compound down into an alcohol

wait 15-20 minutes and take the intended compound.

effects should be felt within 15-60 minutes for most compounds.

WARNING if you get on a piperidine metabolite of something and find you don't want to be on it anymore (as they often are far more potent and/or mental and/or long lasting, often lasting days) some things i have found effectively work as OFF buttons are: carrots, beets/beet extract, ALDH INDUCERS, inhibiting the enzyme(s) responcible for breaking the compound down into an alcohol, ceasing piperidine/dimethylamine intake, ADH inhibitors.

ALDH = Aldehyde dehydrogenase
ADH = Alcohol dehydrogenase

as far as i know ADH attacks most things that pass through the system before ALDH does.

when the enzyme that creates the alcohol out of the compound(s) is maintained induced and ALDH is sufficiently maintained inhibited, and piperidine/dimethylamine is maintained supplied, many compounds will recycle themselves for many hours/days/weeks or more. usually the piperidines seem to cause the long lasting effects for most of the compounds tested.

what i find truly amazing about this process is you can get to know a teacher much deeper because it can often cause the primary effects caused by the receptors the compound(s) effect to become progressively more tolerant, and after a wile you see all kinds of different sides of all kinds of unexpected compounds. it can make many things bi-phasic for many of their receptors they effect.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on October 08, 2012, 10:06:47 PM
taken from (http://herbpedia.wikidot.com/oilahuasca-activation)

that link also contains a very large list of inhibitors for many enzymes that are very usefully once you find out what enzyme(s) can break your compound(s) down into alcohols.

ALCOHOL DEHYDROGENASE

POTENT ALCOHOL DEHYDROGENASE INHIBITORS

Allicin
Acetaldehyde
ALCOHOL DEHYDROGENASE INHIBITORS (Unknown potency)

Caffeic acid
Cinnamaldehyde
Daidzein
Dimethylsulfoxide (DMSO)
Disulfiram
Dodecanoic Acid
Ellagic Acid
Ethanol
Genistein
Isovaleramide
Tween 20
Tween 80
Valerian root
Vanillin

ALDEHYDE DEHYDROGENASE

POTENT ALDEHYDE DEHYDROGENASE INHIBITORS

Calcium carbimide
Daidzein
Daidzin
Disulfiram
Gallic Acid
Semicarbazide
MODERATE ALDEHYDE DEHYDROGENASE INHIBITORS

Kudzu (contains Daidzin)
Soy isoflavones (contains Daidzein, similar to Daidzin)
Durian fruit
WEAK ALDEHYDE DEHYDROGENASE INHIBITORS

Anisaldehyde
Benzaldehyde
Caffeine
Glycerin

in addition most alcohols and aldehydes themselves inhibit the respective enzymes.

a very potent ALDH inhibitor can be made from mixing essential oils of the following:
tangerine, cinnamon, cloves, ginger, orange (sweet), lemongrass, cilantro, allspice, mandarin, lime, spearmint

some of the ingredients may be counter productive, reverse engineering this list starting one ingredient at a time would be the bets method of weeding out problematic oils

i am fairly sure this is referring to the cinnamon oil containing 75%+ cinnamaldehyde
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: caiano on October 09, 2012, 04:29:34 AM
Oh yes,  in fact I supposed everything you stated started from that forum... I'm Muvieri there. ;-)
Thank you to re-collecting the infos  for us, because I've always hard times to find them into that board and, even more,  it's not easy to learn and elaborate correctly the flow of discoveries that happens to read there.



Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on October 09, 2012, 05:10:48 PM
well in honesty compiling all these things in an individual thread dedicated to them will make it much more easy for myself and others to copy the information in whole (that witch we are certain of) to be shared with everyone elsewhere.

but i must admit it is a lot easier when trying to make new discoveries to have the concrete info all in one place instead of digging through the pages over there.

ultimately myself or someone else will move the finally compiled sets of info into their respective threads over their, or create threads if not present yet. 
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 22, 2012, 08:14:10 PM
alright here goes:

some of these enzymes are present in locations outside of the digestive tract.

the goal is to get an aldehyde (alcohols are easily turned into aldehydes), now if you stomach has piperidine or dimethylamine present, and aldehyde dehydrogenase (ALDH stomach enzyme) is inhibited (suppressed) then the aldehydes will pass through without this enzyme breaking them down into acids (acids are not what we are looking for here)

alcohols will be turned into aldehydes by stomach enzyme alcohol dehydrogenase (ADH)

now if ALDH is inhibited, and their is piperidine or dimethylamine in the stomach and you eat an aldehyde(or a compound that turns into one) then it can condense with either the piperidine or dimethylamine (or both if present) the resultying compound is high resistant to metabolism by most stomach enzymes and usually last dramatically longer than its ordinary metabolism by product.

most piperidines created this way are not broken down by ALDH, ADH, mao A or B, CYP enzymes dopamine beta-hydroxalase (i spelled that wrong oh well)

the piperidines metabolites can last for days to weeks if the ALDH  is shut down strongly enough and enough piperidine is supplied.

i have made the piperidine metabolite of bufotenin, and nn-dmt, and 5-MeO dmt and MANY more.

the piperidine bufo metabolite was GLORIOUS! we experience less than 0.1% of the actual color we are capable of experiencing with the blinders up.

and this might be of interest to some, if you take tryptophan  (can be found in supplement form, also present in turkey and sunflower and pumpkin seeds) with the right inhibitors first it actually turns into full on nn-dmt (piperidine metabolite) in your body and brain and it is extremely psychedelic and lasts for days. i have done this with spirulina capsules, its actually scary because it produces ayahuasca like effects for days.

so to make it extra simple:

ingest L-lysine

wait 45 minutes

ingest ALDH inhibitor

wait 15 minutes

ingest desired alcohol or aldehyde.

TREMBLE NEXT TO IT


now if the compound is not an alcohol or aldehyde its possible one of its metabolites are, or that one of its routes of metabolism at some point has it as an alcohol or aldehyde, OR that it can be combined with compounds that are aldehydes or alcohols and then the body recognizes it as one as well.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 22, 2012, 09:10:53 PM
I'm in a mix between pinching myself and wondering why the rest of the world is not privy to this info.  So I have so many questions I can't even muster the courage to ask them.  Best to keep this a secret?  I mean is this info only reported on here by you?  Or is it available on other forums?  How did you learn this?  Or was it taught to you? 

I'm just completely awe struck.  What if one did this and then did...

KAMBO!  What could/would happen?  I have found the Kambo land spirit about 1/2 of my 35+ treatments on myself and I have to say it is my favorite entheogenic vibe.  So if there would be a way to make that "vibe spirit" last for a longer time I would like to try it.  Or I also wonder with these entheogenic eye drops that I use/make called Sananga and the other called Becchete.  Or is it only through the stomach? 

I have so many other questions it's not even funny.  In that case I must ask first if you don't mind me asking a whole heap of questions.  I apologize if you have previously addressed some of what I have asked, I have troubles wrapping my mind around all these brand new earth shattering concepts. 
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 25, 2012, 04:02:53 PM
i somehow missed this post, sorry.

this is posted in detail on herbsmax and drugs-forum, drugs forum responded negatively, it originated from herbsmax when 69ron said that when he took PEA after pepper tea it lasted for days at a time and was scary. i started trying almost everything in this way after this, only few things are not capable of doing this with.

i would prefer you ask the largest most hideously massive list of questions you can possibly muster, the more the better.

with some of the entheogens i partake in the way in witch you ask and word the questions and the content of the questions themselves teaches me more than you are gaining from the answer, among many things one of witch is how to translate complex ideas into the most easily digestible format for your perspective.

"Or I also wonder with these entheogenic eye drops that I use/make called Sananga and the other called Becchete.  Or is it only through the stomach?"

if you know the species names for the ingredients i can look for listed chemical constituents and give you my uneducated guess based on the presence or absence of alcohols or aldehydes or the presence or absence of amines

" I apologize if you have previously addressed some of what I have asked,"

i do not mind at all please ask away, the vast majority of the info is held in the memory of a small handful of individuals and scattered very randomly at herbsmax, this will be one of the first times the information gets compiled into one place, i would like to eventually add posts to the herbsmax wiki.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 25, 2012, 04:11:11 PM
"Or is it only through the stomach?  "

it is NOT only through the stomach, first ask ware you want to do this on the body, and what ingredients then i will see what needs to be done.

if you drink pepper tea without the solids for a few days 2-3 cups a day and or supplement with L-lysine daily  you can easily cycling things that are applied transdermally (through the skin)

after a few days your body gets filled up with piperidine and then the brain starts to get filled, this is why it helps to do it multiple days, as long as you have piperidine in your brain in decent amounts you can do this conversion inside your brain, some of the most powerful experiences i have had with oilahuasca and other cycling experiences were when it did not activate until it reached my brain(i would not be using this specific of descriptions if i had not had 1000-2000 basil oil experiences, so i KNOW when its at what stage of activation and what metabolite i made and how long its going to last and sooooooooooooo many more variables i KNOW instantly as soon as the first shift from baseline occurs.

i can feel the amount of weight behind what i am riding and the channels it is flowing through.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 27, 2012, 07:53:49 AM
Quote
if you drink pepper tea without the solids for a few days 2-3 cups a day and or supplement with L-lysine daily  you can easily cycling things that are applied transdermally (through the skin)

I guess this could be called a dieta of sorts.  I want to start a thread on this cycling method at some point.  It is more intriguing to me for some reason. When you had your spirulina Aya like experience was it with this method?  When you do the EO transdermal do you cycle or do it as is?

For piperine they use black peppercorn fruits, is that the same I use for my tea?  Or just regular old black pepper? 

Does the effect of cycling make it stronger or just last longer?

As you may or may not know Iboga is officially endangered in it's home country of Gabon, so looking for extreme potentiation is a vital resource.  Is it your understanding that this method could conserve Iboga by making effects stronger and last longer, therefore needing vey minute amounts?

Thanks
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 27, 2012, 01:03:18 PM
"  I want to start a thread on this cycling method at some point"

actually you may find this funny but the title of this thread IS the cycling method i just did not put the word "cycling" in the title lol

"When you had your spirulina Aya like experience was it with this method?"

it was not like aya with just caapi it was like full aya brew with dmt and maoi admixtures.

yes i supplied lecithin (becomes dimethylamine) and aldehyde dehydrogenase inhibitors, causing the tryptophan in the spiralina to turn into its alcohol when mao a or b break it down, then the alcohol passes through alcohol dehydrogenase turning it into an aldehyde, witch WOULD pass through aldehyde dehydrogenase but that is strongly inhibited, so the aldehyde of tryptophan condenses with the dimethylamine from the lecithin, this new molecule basically does not pass through mao a or b as strongly as the ordinary version so it becomes extremely potent(, it shifts its metabolism over to the alcohol system, witch if the alcohol route ends up breaking down it then passes through the mao a or b again becoming a alcohol and starting the cycle again.  ( spirulina is very bad choice as it contains extremely little, i took around 20 gel caps lol)

dimethylamine metabolites may pass through mao or b somewhat, wile piperidine metabolites will pretty well not pass through them at all, so a weak non-complete inhibitor for mao a or b could help when using lecithin and making dimethylamine versions of things, wile the piperidine versions of things will probably not matter much if you inhibit mao a or b at all.

"When you do the EO transdermal do you cycle or do it as is?"

when using allylbenzenes EO's transdermally yes i cycle them, i never do allylbenzenes without cyclign them regardless of ruet of administration (even vaporized is possible, but very strong because the metabolites are almost created solely in the brain)
on the other forum we ditermined that all the allylbenzene EO's could be cycled (things like basil EO, nutmeg EO, persley seed EO, etc etc)  some oils do not have allylbenzenes in them, but some do have aldehydes or alcohols as some of their active ingredients, these aldehydes and alcohols can be cycled, any amines can be cycled, anything that can be broken down by the body into an amine, aldehyde, or an alcohol can be cycled.

"For piperine they use black peppercorn fruits, is that the same I use for my tea?  Or just regular old black pepper?  "

yes you want regular ground black pepper i think 1-2 tablespoons, put in coffee filter, twist the opening closed and seal with twist tie and put into cup of boiling water let steep for maybe 5-15 minutes and drink either stand alone or with noodles or soup as the broth.  you want to avoid piperine (in the solids, will not extract into water) and go for piperidine (gets extracted into the water), this is why you put the ground black pepper into a coffee filter and twist the opening closed and then seal it with a twist tie so none of the pepper solids go out into your water, so when you drink it you only get the piperidine that got extracted into the water, and none of the piperine from the solids.

"Does the effect of cycling make it stronger or just last longer?"

both, very strongly.

"As you may or may not know Iboga is officially endangered in it's home country of Gabon, so looking for extreme potentiation is a vital resource.  Is it your understanding that this method could conserve Iboga by making effects stronger and last longer, therefore needing vey minute amounts?"

yes this could be used to make massive shifts towards saving the species, EXPECT literally expect the plant teacher to gift you EXTREMELY strongly if you sit down hone your intentions in a pure heart attempting to work and do what you CAN do from your position to help prevent its endanderment, and then partake in seremony, you can almost EXPECT the plant teacher to extremely strongly favor you and show you many extremely deep wisdoms and magics with witch to accomplish the goal, and then you can expect that if you dont first use those magics to aid the plants survival before other uses, you will be punished by yourself for squandering the gift, as the plant will contract with a part of yourself that is sensable and knows their must be pure intentions every step of the way and this part of the self is the guide for the ordinary self we take part in.

i found on wiki data detailing metabolism, i will soon post what needs to be done to cycle ibogaine, and potentially how it could be diffirent from traditional iboga.

other things that will very strongly potentiate iboga are the list of NMDA antagonists i PM to you, take them all 30-60 minutes before iboga.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 27, 2012, 02:08:07 PM
now both ibogaine (12-Methoxyibogamine) and Noribogaine (12-Hydroxyibogamine) both seem to be able to be cycle because they are amines


i am currently looking up the receptors ibogaine alone hits, wile wiki lists the following for Noribogaine:

"Noribogaine is most potent as a serotonin reuptake inhibitor and acts as a moderate κ- and weak µ-opioid receptor full agonist"

the serotonin reuptake inhibitor part means temporarily during its effects the serotonin system is somewhat suppressed but upon the effect wearing off their is a permanent increase in the reuptake of serotonin, that is only reversed with continued over-activation of that system most usually by drugs of abuse.

one of the iboga effects are hallucinations from 5HT2A agonism, this is the primary receptor most psychedelics effect, downstream (downstream means activating this causes the activation of) this agonizes dopamine 2 receptor (D2), some compounds don't start with 5HT2A at all and instead directly effect D2 like salvia and cannabis, the primary effects of cannabis are D2 agonism, hard drugs like meth and cocaine the dream states these can cause are also caused by D2 agonism. lsd has a D2 agonism component.

now iboga is good in chronic micro doses (multiple reasons this is just one) because its kappa agonism increases the amount of D2 receptors in the brain, so that its 5HT2A agonism has more D2 receptors to flow into downstream.

the kappa opiod agonist part means you will get dynorphin, and your D2 receptors will be upregualted meaning increase the amount of receptors on the cell (addiction downregulates, anti-addictives upregulate)

dynorphin is the primary feeling of dread or loathing or dysphoria produced by drug withdrawal, intense exercise also produces dynorphin release. dynorphin itself agonizes kappa receptors. agonizing kappa receptors also releases dynorphin.

regardless of the means of activation agonizing kappa receptor reverses addiction in many key areas, it does not fix it, it pushes the bar in the right direction, in the same way abstaining from drugs for long periods would, so its kind of like speeding up time, agonizing this receptor as far as drug withdrawal is concerned because you can concentrate strong withdrawal of the drug into a short period of time and be done with it instead of dragging the dread out for weeks and months.

its effects on µ-opioid receptor are weaker than for kappa this is good, this receptor will give it a little bit higher of a serotonin phase in the beginning, it also makes this compound very useful for pain treatment and addiction treatment, because the NMDA antagonism makes its µ-opioid agonism non-tolerance creating, and the kappa agonism reverses the tolerance the user already had before ingestion.


the more CYP2D6 enzyme present in the stomach the less ibogaine you will get and the more Noribogaine you will get below is a list of inhibitors for that enzyme witch will cause ibogaine to be active alone taking much longer for the enzyme to recover and turn ibogaine into Noribogaine.

i will post more when i find out what ibogaine does alone.

i realize all this sounds fairly complicated at first, but you have to understand i am no student in any university or college, the psychedelics lead me to interest in how ABSOLUTELY everything effects the way i feel and my health and i take it as a form of creative expression to find out these things(there is no right or wrong just learning), once you truly understand the connectivity of all the systems in the brain and body and have a good relationship with psychedelics you truly hold the keys to the the mysteries of nature, the physical design and structure of the physical body and its micro systems, reflects perfectly the structure of the spiritual bodies and realms and their structure. the design of the structure comes from the same source.


POTENT CYP2D6 INHIBITORS

Cannabidiol (from Cannabis)
Echinacea purpurea
Goldenseal
Pomegranate juice (Punica granatum): 1 cup
Pummelo
Saint John’s Wort (high dose)
Starfruit juice
White grapefruit juice: 2 cups
MODERATE CYP2D6 INHIBITORS

Black pepper: 5 grams (ingest the solids, it's an ineffective inhibitor as tea)
Calamus EO: 3 drops
Kava
Pi. cubeba
Quercetin
Zingiber aromaticum
WEAK CYP2D6 INHIBITORS

Alpha-asarone (found in Calamus EO)
Black cohosh
Capsaicin (found in cayenne pepper, habanero peppers, etc.)
Cayenne pepper
Common sage
Cryptotanshinone
Curcuma heyneana
Curcumin
German chamomile EO
Ginkgo biloba
Habanero pepper
Milk Thistle
Safrole
Tanshinone I
Turmeric
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 27, 2012, 02:18:05 PM
i have a high level wizard friend who can distinguish most of the dopamine receptors by the color of hallucinations they cause.

personally the only thing i can think of that is similar to that is from dosing yin on left and yang on right half of body i can feel dopaminergics or serotonergics very distinctly when taken now.

yin = serotonin

yang = dopamine

also if you take these you will get more Noribogaine effects and less ibogaine effects:

CYP2D6 INDUCERS

Valerian root
Valerian root EO: 2-5 drops

i am still looking up the effects of ibogaine alone without noribogaine will post when found.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 27, 2012, 10:50:26 PM
Quote
"As you may or may not know Iboga is officially endangered in it's home country of Gabon, so looking for extreme potentiation is a vital resource.  Is it your understanding that this method could conserve Iboga by making effects stronger and last longer, therefore needing vey minute amounts?"

yes this could be used to make massive shifts towards saving the species, EXPECT literally expect the plant teacher to gift you EXTREMELY strongly if you sit down hone your intentions in a pure heart attempting to work and do what you CAN do from your position to help prevent its endanderment, and then partake in seremony, you can almost EXPECT the plant teacher to extremely strongly favor you and show you many extremely deep wisdoms and magics with witch to accomplish the goal, and then you can expect that if you dont first use those magics to aid the plants survival before other uses, you will be punished by yourself for squandering the gift, as the plant will contract with a part of yourself that is sensable and knows their must be pure intentions every step of the way and this part of the self is the guide for the ordinary self we take part in.

REVOLUTIONARY dear brother!  This is giving me so much hope and optimism.  Let's continue these movements forward at warp speed.  Thanks for giving me this time to catch up a bit. 

I'm considering now posting whatever you write on the eboka forum as this is some of the most advanced Iboga infor I have come across.  Only with your permission of course.

Thanks again,
KP
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 27, 2012, 11:01:43 PM
So are you saying rather than doing the "Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation" cycling for Iboga instead one would utilize the CYP2D6 INHIBITORS?

Many seek the Noribogaine effects as this is filled with positive bliss.  If you can hone this one out...BOOM BUHM! 

If you can distinguish possibly (PLEASE) the two different inhibitors needed for seperately Ibogaine and then for Noribogaine in the section titled under Iboga and Kambo I would appreciate it.  I will move your topics to that section with your permission or you can do so. 

Breakthroughs!  Even if we're the only ones noticing. 
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 27, 2012, 11:44:00 PM
"I'm considering now posting whatever you write on the eboka forum as this is some of the most advanced Iboga infor I have come across"

permission granted


"So are you saying rather than doing the "Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation" cycling for Iboga instead one would utilize the CYP2D6 INHIBITORS?"

i am saying combining for iboga to get Noribogaine to cycle:

piperidine (black pepper tea or L-lysine)
ALDH inhibitors (grocery store natural almond and star anise extracts) (or just tea made from whole star anises)

and then an CYP2D6 INDUCER like valerian, it could take anywhere from 30 minutes to over an hour after taking valerian for its induction to kick in.

so the timing would be for noribogaine:

pepper tea without solids (or l-lysine) and valerian at the same time

45 minutes later

20-40 drops each of natural star anise extract and almond extract from grocery store, sewing needle pokes small enough holes for drops in the foil seal, if put in gel caps with olive oil and taken followed right after by half peanut butter sandwich it is infinitely more enjoyable. or if your lazy you could eat 20 drops of each and apply 10+ drops to the skin above the liver and or along the meridians connected with the stomach and intestines and such, taking a caffeine tablet with these extracts at the same time will boost the ALDH inhibition very strongly.

15 minutes later

take ibogaine (possibly best if taken in gel caps, mixed with olive oil might help as well, and with very small bite of peanut butter sandwich)

if one cannot get valerian, they could take any of the short lasting INHIBITORS listed, the day before taking piperidine and ALDH inhibitors, and the next day after taking the short lasting inhibitors they will have long worn off with a high probability of the body slightly inducing the enzyme upon recovery from the inhibitor, you could do this by combining inhibitors under "weak" or "moderate" in extremely small doses the day before trying to cycle Noribogaine.

ibogaine without noribogaine:

if you wanted to cycle ibogaine alone without noribogaine effects (or very little noribogaine) you would do the same thing but make sure not to take valerian and instead ON the day of the cycling you would take strong CYP2D6 inhibitors at the same time as the ALDH inhibitors, in both set-ups you take the piperidine or dimethylamine 45 minutes before the ALDH inhibitors.

"Many seek the Noribogaine effects as this is filled with positive bliss.  If you can hone this one out...BOOM BUHM!  "

do you mean what needs to be done to get only Noribogaine? simple, dose valerian an hour to an hour and a half before iboga, if you cannot get your hands on valerian, then the day beforehand dose a combination of short lasting weak-moderate strength inhibitors from the list, then the next day when you take the iboga, you take it EXACTLY 15 minutes after the time you took the inhibitors the day prior.

your bodies enzyme runs on a tight schedule and if you inhibit or induce something they get written down in the schedule and your body expects to be repeating that act at the same time everyday this becomes more and more strong the more days on the EXACT same timing you take an inhibitor or inducer.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 28, 2012, 12:06:25 AM
I guess I'll have to give it a go in the coming months.  No one else has done this I suppose?  This has me brimming with excitment.  Just trying to comprehend all of this and hoping other like minds are paying attention to what you are saying. 

I'll post around and see if others get the hint or can vibe the frequency.  Honestly I think people are not gonna get it, just throw in the towel and say "too complicated".  So best I try it first and see how it goes. 

Thanks again and WOW!
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 28, 2012, 12:45:00 AM
wait.......... are their native groups that micro dose iboga daily?... if so i have some insights to share about what they are causing to happen by doing this.

if you dose iboga for many days in a row and then stop 1-2 days before a higher dose or flood, you will get strong Noribogaine effects, because ibogaine inhibits CYP2D6 when the enzyme breaks it down, if you do this the same time everyday, then the body eventually starts to retaliate by overproducing the enzyme to compensate, so the first few experiences are mainly ibogaine and the later experiences should all be highly noribogaine.

"No one else has done this I suppose?"

untouched soil friend, tread lightly (:
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 28, 2012, 10:43:45 AM
I see now, only now, that this thread started wanting to see if the cycling would work with Kambo.  So far you have had several ideas for vastly conserving/potentiating Kambo through these ingenious methods.  I'm willing to donate to the cause, I can't say I am brave enough to try the cycling with Kambo.  But would be encouraged to do so if it proved fruitful.  And that would change everything in the Kambo field. 
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 29, 2012, 01:29:45 AM
i am not sure if the direct kambo compounds can be cycle but i can garantee when you puke and feel like your dying, thats what i call a dynorphin threshold experience, when the pain is so great, you actually learn things from it.

the dynorphin itself i am sure can be cycled, dynorphin has to be a part of the downstream effects of kambo.

i know dynorphin can be cycled because when i take the cycling method followed by peppermint EO and go exercise to the point of blacking out i wake up and have waves of dynorphin for hours coming and going, this only happens to an extremely small amount if i omit the peppermint EO, and its much harder to black out if i leave the peppermint EO out, this is because it supresses the endogenous opiate system temporarily, and if you exercise very intensely early after doing this your body does not recover from the peppermint EO's kappa agonism and dynorphin release fast enough and you cut off the fuel your body needs to push past its limits, after already having surpassed the limits, causing crash or black outs, i only get black outs because i am anemic and eat a very strict diet and lose myself playing the drums.

this feels so much like the time i cycled salvia and i have so much experience with exercise based entheogens (methyl chavicol, PEA) and drug free exercise that i am certain if you every feel like your dying on kambo its likely hitting SOME of the same receptors that salvia and intense exercise hit, as well as pepprmint EO.

this next part is somewhat related

because of thousands of methyl chavicol doses no matter if i am sober or not when i get to a certain point of exercise i get entheogenic effects as if on higher stages of methyl chavicol, its effects are like a cross between mescaline and lucid dreaming, its lucid dreaming quality is extremely present in the peripheral nervous system, your body and head feel the same way you feel the first few seconds after waking from deep dreaming, extremely relaxed but very much able to move any way you choose with no effort, extreme nerve control.

its effects also include being able to use your concentration to hyper effectively channel your bodies energy (from all sources, meridians and chakras and more) into any part of your body you concentrate on. i am talking about something scientific here, not just things that are difficult to attain because they require facing demons first like most energy matters.

it adds the qualities of a neanderthal on top of your regular brain power, so you can look at something (time will also be dilated) and think up all the possible ways to go about any intentions you have about that thing, and then you can enact the intentions with so little effort it is like your dancing, it makes it enjoyable, and you can do STUPIDLY amazing feats in this state.

in short it is capable of bringing out your latent pre-cognition, and then it makes nerve control so strong you have the plan, and the timing and skill, you literally can manipulate reality as if it were in the movie the matrix.




Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: marypoppins on November 30, 2012, 03:38:38 AM
great stuff here
healing potentials expound

here's a big question ?

is seems very possible that some case of chronic schizophrenia might actually be where a person's enymes etc are converting something the person is eating into an  alcohol form and producing altered states
this might also explain some people's acute psychotic episodes ?

perhaps some people's unique behaviours are being cause by enzyme inhibitors and instigators that is being caused either by their unique biochemistry or food they are eating

????
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 30, 2012, 01:04:27 PM
mary this sounds like a very good possibility, you have to learn to not take all the extremely frightening aspects of this types of substance as anything but a form of communication we are to primitive to interpret correctly yet, but we can on an individual basis slowly step by step overcome this communication gap, and come to learn from EVERY type of experience.

i dont believe in mental disorders anymore, i believe in mercury, flouride, bromides, and chlorides these are the likely culprits coupled with eating the disease(post-birth software programming).

after you have an extremely strong ego death you are presented with a return to your innate pre-birth hardwired programming, with this you can conceive new ideas and materialize them(immaculate conception) but if you eat the disease the tree of life inside your body is suppressed, take everything you perceive(the disease) with a grain of salt and ASSUME it has endless meanings in countless different languages and perspectives, never put an idea down as "understood" never let the curiosity truly die and have yourself convinced you "figured something out" instead the first language or perspective in witch you were presented each part of the disease should be a extra lesson in comparison to the countless others lessons it can teach you from all other languages and perspectives.

the reason i say i "dont believe" in mental disorders let me explain it like this, i used to be really crazy, now i am really strong.

i don't want to post the description of some of the strengths i have developed because its to expressive for the majority to be able to accept properly.

to simplify it, YOUR GREATEST WEAKNESS IS YOUR GREATEST STRENGTH IN DISGUISE, unrealized sitting squandered in prejudiced due to negative emotions you attach to it.

i would go as far to say that people with mental disabilities have a gigantic pre-disposition to bio-electromagnetic energy.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on November 30, 2012, 02:52:18 PM
Another inspirational breakthrough, thanks for this.  This forum was started in all honesty not just for my love for Kambo but my love for cutting edge healing modalities.  The two of you meeting is quite golden in this quest. 

I wonder with all these techniques if you (Peaceful Warrior) have started working with others to heal them?  I'm interested in seeking you're paradigms, so much so to focus on your modalities. 

As you said in the mission to save the endangered Iboga, you cut one head off and many new form.  That being said I'm feeling quite confident that your overall approach is so multifaceted as to slay an infinite headed dragon. 

Much appreciation again and again.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 30, 2012, 03:31:20 PM
i think i was on here someone stated a shaman once said "i hold but the power of a dead frog, it is in the individual whether or not to be healed"

i am not sure if flouride, mercury, bromides, chlorides are solely the reason for people acting the way they do but i am certain that the VAST majority of people i have met in my life are not ready for healing.

so the trick is you have to secretly trick them into getting their 5th, 6th, and possibly 7th chakras open before you can heal them, because they 5th and 6th being unbalanced causes them to be incapable of seeing the merits of asking or accepting help from others OR THEMSELVES!

i see healing in a different way. i am never not healing. every act you perform is a example set for all future descendants. only 1 dna pool all are brothers/sisters, before the dna, only one source, before the source of reality only infinite post-dimensional reality matrixes, beyond this one source, beyond this, one non-source, beyond this THERE EXISTS ONLY YOURSELF.

follow the stream to the source, keeping going past all sources, till you reach the highest echelons of up-stream, don't be surprised if you find yourself at the top.

we are living a game reality in the school of earth, we are simultaneously living the life of every microorganism that makes up our body, and our body, is everything in the post-dimensional, homecoming eclipsed finality beyond the miniscule limitations of space and time.

when intuition eclipses perception and memory, and this new expansive means of perception succeeds the current actuality of realities expanded future potential, you find that your body, is all that is, all that will be, and that has been, and all unknown, and more, all that is not, all that will not, has not, YOU GREW A HEAD ON THE SIDE OF YOUR BODY AND PUSHED YOUR PERSPECTIVE INTO THAT POINT AND NOW THIS IS THE REALITY WE ARE LEFT WITH right here in the NOW.

i dont heal people, i feed their ego, so that when the beast is nice and ripe they can sit down and have a feast upon themselves. and from eating ones self they will learn to follow themselves.

i can teach people telepathy, pre-cognition, remote viewing, instant materialization, body jumping, shape shifting, and many more.

i do not wield these powers, i occasionally play with them so i may learn to teach them better, i know how to do these things but i give them to others instead of using them for myself.  unfortunately most others are trapped in the flouride, mercury, chlroide, bromide matrix so they cannot see past their post-birth software programming. and genuinely are incapable of allowing themselves to accept the possibility that these abilities are sitting within their body waiting to be put to use, they must squander the gifts in ignorance until they are overwhelmed by the sensation of loss that comes from having to lose something to realize what you had, but they never really lose it, they just need to feel they have strongly so they can learn to stop squandering it.

doubt is the ABSOLUTE most problematic addiction people have, people are more addicted to doubt and prejudice than anything else on earth,  they have to live it countless infinities over before they will let themselves take one step forward.

HOPE is the ultimate strength, in all its forms, take the hope with a grain of salt and remember if doubt creeps in don't let it dirty your opinion of hope with negative attachments.

when you open the box, all the negative attachments to the demons leaves you and your left with infinite hope, and the hope is so infinite it actually succeeds all of reality, allowing for instant materialization, its the hope to turn the weaknesses caused by all the demons into strengths.

i may post that post that is still glitched into another thread, as it is somewhat related to how i see healing.


Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on November 30, 2012, 03:40:57 PM
"As you said in the mission to save the endangered Iboga, you cut one head off and many new form.  That being said I'm feeling quite confident that your overall approach is so multifaceted as to slay an infinite headed dragon.  "

i have no doubt i could kill an infinite headed hydra if i wanted, but lol  you got what i was saying wrong with that one reference.

i meant when the government(prohibition) and ignorant humans(biopiracy) cut off one head from the hydra, infinite new heads spill forth from the newly opened seam. as in if they extinct a species they are making the mess worse and that witch they were trying to suppress will outgrow their suppression infinite fold.

this is how i feel about the government, i say "try it *itch see what you **ing get!" cut this flowers head off or mine it does not matter we will come back with infinite unrecognizable forms from behind your potential perception, we will COME FROM UP STREAM IF NEED BE.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: ―λlτεrηιτγ- on December 01, 2012, 12:36:02 AM
This thread is so mind-blowing I had to walk away for a moment and come back. thanks for sharing warrior. I've read about this at herbs.maxforum but this thread made it easier for me to get my head around. good posts.

Quote
other things that will very strongly potentiate iboga are the list of NMDA antagonists i PM to you, take them all 30-60 minutes before iboga.

Why would NMDA antagonists potentiate iboga? Isn't iboga an NMDA antagonist? These things won't compete and cancel each other?
Which sort of things would you use? Magnesium, Zinc, German chamomile? How does this work?

Quote
also if you take these you will get more Noribogaine effects and less ibogaine effects
And vice versa. This is a pretty amazing break through.

Especially to be able to get primarily Noribogaine effects and then cycle it. But Noribogaine already stays in your system a long time.
So this would make it stronger, granting the ability to use less plant alkaloid? And continuing this everyday at the same time would keep the effects more pronounced, until you stopped, at which point the Noribogaine would continue to carry on doing its thing more subtly for the rest of the duration of the 4-6 months of its stay in the body? theoretically.

Quote
so the trick is you have to secretly trick them into getting their 5th, 6th, and possibly 7th chakras open before you can heal them, because they 5th and 6th being unbalanced causes them to be incapable of seeing the merits of asking or accepting help from others OR THEMSELVES!

How can this be done?  :D
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on December 01, 2012, 01:57:31 AM
"Why would NMDA antagonists potentiate iboga? Isn't iboga an NMDA antagonist? These things won't compete and cancel each other?
Which sort of things would you use? Magnesium, Zinc, German chamomile? How does this work?"

NMDA antagonists synergise especially if the strongest or best one is taken separately 30 minutes after the others are all taken at once.

don't take german chamomile it inhibits CYP2D6 causing more ibogaine to be made and less noribogaine

prolactin inhibitors:   (will also enhance strength, will improve ability to assimilate experiences) taken chronically and also in high dose 45-30 minutes beforehand

vitamin B6
vitamin E
zinc

tumbs or peppermint EO will make ibogaine substantially stronger if added with chronic use should be extremely powerful, enhances absorption and reduces tolerance.

NMDA antagonist:        30 minutes beforehand

magnesium
zinc
parsley
garlic (fresh, chewed and swallowed)


extra vitamin c will also help

and possibly a mouth full of dxm 10 minutes after the others, followed 15 minutes later by ibogaine.

this would be extremely powerful to even micro dose ibogaine with all of these admixtures taken at the specified times.


"So this would make it stronger, granting the ability to use less plant alkaloid? "
yes, yes

"And continuing this everyday at the same time would keep the effects more pronounced, until you stopped, at which point the Noribogaine would continue to carry on doing its thing more subtly for the rest of the duration of the 4-6 months of its stay in the body"

it would likely make it dramatically more potent at very small micro doses.

NMDA antagonists up-regulate NMDA receptor in the long run, causing improved intelligence.

"How can this be done?"

tell them they get infinite wishes granted if they do it. (this is true)
some will still be unwilling to try oils or other things that balance chakras.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: ―λlτεrηιτγ- on December 01, 2012, 04:42:32 AM
Do you mean Tums? I would prefer to use pure calcium carbonate. Tums has mineral oil and stuff in it that I wouldn't want to ingest.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on December 01, 2012, 01:37:32 PM
i mean tumbs, for the menthol not the calcium carbonate
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on December 01, 2012, 01:53:50 PM
FYI...

I'll be reposting all Iboga entries here in the Iboga section.  Just too important to get lost in the mix.  In a couple months I hope and pray for some major breakthroughs.  The conservation of Iboga is a must and this would be an amazingly effective method to do so. 

I've thought about it a lot maybe the name of this thread could also be "Nothing else matters".  Although that might just be how my obsessive mind works. 

Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: Kambogahuasca Panacea on December 01, 2012, 01:57:26 PM
http://www.mountainroseherbs.com/search/search.php?refine=y&keywords=Menthol+Crystals
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: ―λlτεrηιτγ- on December 01, 2012, 03:06:45 PM
Amazon has 2 oz for $4 (http://www.amazon.com/gp/product/B003SA85F6/ref=gno_cart_title_1) as well.
Title: Re: Aldehyde dehydrogenase inhibition + piperidine or dimethylamine supplementation
Post by: peacefull warrior on April 27, 2014, 09:54:48 AM
sometime soon i am going to test cycling kambo by applying the kambo as normal into burns, but i will be supplying lots of piperidine and or dimethylamine orally and inhibiting ALDH very strongly before application.

i will take ALDH inhibitors orally and topically to the location before burns are made.

i am intending on starting off with 1 small dot and if this does not do much after an hour i will add 2-3 more dots after taking more ALDH inhibitors.

i will most likely apply it to my shoulder/upper arm as i have seen done often in the traditional use, as this seems a standard place for dots and would be more predictable in its effects as compared to say ear application or 13 ghosts, 7 dragons, etc etc