Hey Tengri, welcome to this quiet forum. I haven't posted in quite some time, but thought I'd share with you that I too have experienced similar reactions to this medicine. I've been working with kambo for several years and anytime I take a significant break (at least a few months), the first time I apply the medicine again I will end up struggling through the night with what you described -- restlessness, anxiety and racing thoughts. I take it to be an immune response of some sort or it could even be viewed as a dislodging (purging to partial purging) of stuck energies or re-balancing of hormones (all guesses, of course) . Mine usually subsides before the second night, however it has lasted a few days once or twice.
At any rate, I wouldn't be deterred from giving this medicine a chance if I were you. More than likely you'll come out the other side better off, although kambo can certainly stir things up a bit. I've gained a lot from the frog vaccine and I usually find that my physical health and ability to withstand stress improves because of it and also, good things seem to come into my life at opportune times that seem to correlate with using the medicine, synchronicities aligning and all. It sort of helps one to get on the right track with their life, imo.
This initial reaction should settle down and it could very well be that you got a huge immune boost and are experiencing your body attacking disease, imbalance or uncleanliness within.