An example might be tightness in the throat, and a hard time swallowing. Microdosing as an allergy test is done with all sorts of biologically active drugs by cautious people, including psychoactive research chemicals. As the majority of people aren't going to have an allergic reaction to kambo, it's really up to the one administered the kambo to decide if it all seems copacetic, and if they want to push it to an agreeable full dose.