N-methyl-D-aspartate (NMDA) antagonists resensitize the brain receptors to serotonin and dopamine, thereby lowering drug tolerances and diminishing withdrawal symptoms.
They also reduce binge/compulsive eating. (
https://www.ncbi.nlm.nih.gov/m/pubmed/25381776/)
E.g.:
Memantine
Amantadine
Ibogaine
Harmine
Harmaline
Norharmane
Tetrohydroharmine
3-Methoxyphencyclidine
Methoxetamine
4-Methoxyphencyclidine
(Beware of local laws; Some of these compounds may be illegal)