Ethnobotanical Kambo: Phyllomedusa Bicolor > The Science behind the Magic (Kambo info to convince left brainers)

HIV and frog peptides

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Bamaboy:
Hello new to this forum, I found about this forum from reading the antimicrobial properties of kambo after finding out that I was diagnosed with HIV.  I know little about the disease other than what is conventially taught as prevention, so since I have not been on medication for any chronic condition all my life I searched for 'frog peptides' and hiv and found something interesting in one study that could be similarly true in the kambo medicine.

I am currently on pharmaceutical meds that work pretty well (Atripla), so far it works pretty well as far as no severe side effects.  I get vivid dreams, some wooziness, and the most visible is a pale colored rash on my face and neck.  I will continue my meds because it has proven to reduce the hiv viral loads to undectectable in patients.  The problem is that these meds cost approx $2000/mo and I'm only getting them because I'm in a rehab housing program, with no income so the state pays for the meds for now.

The meds stop hiv from replicating and infecting the t-cells and slowly allows the immune system to rebuild.  I was told by the social worker and nurse that adherence to the drug everyday is crucial for working otherwise the virus can mutate and the meds stop working which id have to go on another med.

So eventually I am considering going off the meds after much contemplation, a risky move, because of some interesting properties of these frog peptides to not only kill the HIV virus but to go in the dendritic cell where it is hiding as a Trojan horse and disrupt it, thus making it more of a possible cure if it can be done within the whole immune system.

Dermaseptin in the P. bicolor frog secretion and only one study I found referenced in one study where it penetrated the dendritic cell, but not the more powerful peptides tested that showed 80-99% inhibited the HIV virus found in the c.  Interesting thing is that these two frogs look similar, both green and apparently the latter is a common 'pet frog' which makes me wonder if a 'frog peptide' stick can be easily created much like kambo is done.

Some interesting leads I found regarding all this.............
Frog Peptides Block HIV In Lab Study
http://www.sciencedaily.com/releases/2005/09/050930080923.htm
A new weapon in the battle against HIV may come from an unusual source -- a small tropical frog.

Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells
http://jvi.asm.org/content/79/18/11598.full

ABSTRACT

Topical antimicrobicides hold great promise in reducing human immunodeficiency virus (HIV) transmission. Amphibian skin provides a rich source of broad-spectrum antimicrobial peptides including some that have antiviral activity. We tested 14 peptides derived from diverse amphibian species for the capacity to inhibit HIV infection. Three peptides (caerin 1.1, caerin 1.9, and maculatin 1.1) completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells. These peptides also suppressed infection by murine leukemia virus but not by reovirus, a structurally unrelated nonenveloped virus. Preincubation with peptides prevented viral fusion to target cells and disrupted the HIV envelope. Remarkably, these amphibian peptides also were highly effective in inhibiting the transfer of HIV by dendritic cells (DCs) to T cells, even when DCs were transiently exposed to peptides 8 h after virus capture. These data suggest that amphibian-derived peptides can access DC-sequestered HIV and destroy the virus before it can be transferred to T cells. Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs.

According to the graph on the full report, Dermaseptin (also found in P. bicolor aka kambo) inhibited the virus 40% which makes me wonder if repeated kambo treatments would have cumulative effects and since this is just one study what other peptides could be at work.

Glad to see the journals like Jox has set up, and am thinking of doing something similar once I can get my blood tests as a measure of my progress, this could be towards the end of the year.

―λlτεrηιτγ-:
Very interesting. I'd also load up on a bunch of antiviral herbs and such. I'd love to try the Litoria chloris frogs excretion in the same way as kambo. or mixed with kambo.  ;D

―λlτεrηιτγ-:
Has anyone tried Kambo with a different species of frog's peptide excretions? This is majorly exciting imo. Too bad that australian red eyed tree frog seems pretty rare. I used to breed rare and delicate gecko species for years. I think it'd be very cool to get a couple of these frogs and treat em very well.

here's a very common pet store frog
Peptides protect from fungal infection: African clawed frog
http://www.asknature.org/strategy/105d089b5615f7d6afb320619016c94c

Australian Green Eyed Frog Anti-microbial secretions
Litoria_genimaculata
http://www.cosmosmagazine.com/news/5428/frog-skin-secretions-battle-superbugs

Rana nigrovittata anti-microbial
http://onlinelibrary.wiley.com/doi/10.1002/psc.1309/abstract

The skin secretions of the australian green tree frog have antibacterial and antiviral properties
this looks promising. one website lists 7 peptides. This is a popular pet store frog.
http://en.wikipedia.org/wiki/Australian_green_tree_frog

http://www.soci.org/Chemistry-and-Industry/CnI-Data/2011/7/Frog-peptides-ready-to-make-the-leap
this page lists eleven different frogs and their peptides.

"One substance isolated from the skin secretions of the Foothill Yellow-legged Frog — a species once common in California and Oregon but now facing extinction — shows promise for killing methicillin-resistant Staphylococcus aureus (MRSA) bacteria. MRSA is a 'superbug,' infamous for causing deadly outbreaks of infection among hospitalized patients. Now it is occurring in settings outside hospitals, including schools, nursing homes, and day care centers.

"The skin of the mink frog, likewise, contains secretions that show promise for fighting 'Iraqibacter,' caused by multidrug-resistant Acinetobacter baumanni.


interesting book. probably too scientific and over my head.
http://www.amazon.com/Handbook-Biologically-Active-Peptides-Kastin/dp/0123694426/ref=sr_1_2?s=books&ie=UTF8&qid=1357650777&sr=1-2&keywords=frog+peptides

Bamaboy:
Thanks lots of interesting applications which look like it would be part of a medicine cabinet.  Been doing some more reading on the White Tree Frog and found this interesting bit which makes it seem possible of making a peptide stick

"Waxy skin secretions, similar to that of frogs of the genus Phyllomedusa, help to prevent dehydration. And like these frogs, L. caerulea will smear these excretions all over itself to protect its delicate skin from the elements."

http://www.frogforum.net/content/white-s-tree-frog-care-litoria-caerulea-121/

cool beans :)  looks like I'd be a guinea pig to try this out

―λlτεrηιτγ-:
Bamaboy,

Look into getting some Echinacea for the immune system. Echinacea stimulates T-cell production, in fact in as little as two or three weeks you can double, triple, even quadruple the amount of T-cells in your body with good quality Echinacea root. Poke root and ginseng as well.

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