not to take away from any work being done, or to be done, but i like to think of substances as training tools to help teach how to use the respective systems with ones intent, will, etc etc
Thats a cool way to think of it. I haven't figured out how to use my intent/will to replicate the effects of many substances though. I can enter a state similar to that induced by hapi and other dopamine releasing substances through meditation though, which is fairly interesting.
PAM and NAM are temporary as is ALMOST every substance related alteration i have found, even the ones that seem to be non temporary seem to have ways of showing the non permanence beneath all, transience takes all forms even permanence.
Thats how it goes. However, if a substance causes a new neural pathway to form, then it becomes natural to stimulate this neural pathway in ones every day state, this change will be permanent.
BTW lets not derail the thread into a discussion on taurine. Lets keep it focussed on NMDA antagonists in general, and related (in this context) classes of substances.
There is more to the anti addictive properties of NMDA antagonists than NMDA antagonism itself. Further down the metabolic cascade is the release of nitric oxide (i.e. NMDA activation leads to the synthesis and subsequent release of more nitric oxide) and nitric oxide inhibitors like methylene blue have similar anti addictive properties. I wonder if there are any natural NO inhibiting substances known.