This is the flu receptor. Agonizing it reduces dopamine and norepinephrine release (not sure where but likely system-wide). Agonizing it causes the direct sensations of the flu: lack of energy and lack of wellbeing. Many entheogens agonize this receptor, directly contributing to negative sensations felt during the agonization phase, but also contributing to feelings of wellbeing during the withdrawal.
Antagonizing this receptor causes feelings of euphoria, wellbeing, and magic. It directly counteracts the sensation of the flu, and amplifies any euphoric feelings. It has been theorized that this is the "magic" receptor of MDMA. It is also possible that cocaine antagonizes this receptor, however this has not been proven and needs further investigation. It has, however, been proven that antagonization of 5-HT2c in conjuction with cocaine administration increases the reinforcement of addictive pathways.
However, when used with 5-HT1a agonists alone, it seems to provide more of an antidepressant ability to see the magic of reality again, rather than anything addictive. There is no significant withdrawal from this.
Noticeable ligands:
Kudzu (Puerarin, which is also a 5-HT1a agonist and a GABA-A antagonist)
possibly Happiness Tree
