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Messages - ―λlτεrηιτγ-

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316
Norbufotenin Structure
https://en.wikipedia.org/wiki/N-Methylserotonin#/media/File:Norbufotenine.svg

Vs.

Bufotenin Structure
https://upload.wikimedia.org/wikipedia/commons/0/04/Bufotenin_structure.svg


Also started a thread inquiring for more information at https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=70650



Quote
N-Methylserotonin. 5-Hydroxy-N-methyltryptamine.
http://www.chemspider.com/Chemical-Structure.132989.html

So this would be 5-HO-NMT.

http://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5131

So as with NMT and Bufotenin it is probably destroyed by mono amine oxidase.

Quote
NMT has been found in the bark, shoots and leaves of several plant species, including Virola, Acacia, Mimosa and Desmanthus
Quote
Orally administered NMT appears to produce no psychoactive effects, likely as a result of extensive first-pass metabolism.[3] However, it may become active upon combination with a MAOA inhibitor (MAOI).[3] By vaporization NMT shows activity at 50–100 mg, with a duration of 45–70 minutes; duration of visual effects 15–30 seconds. Effects are primarily non-visual.
https://en.wikipedia.org/wiki/N-Methyltryptamine

^^And most of us thought the effects of those plants were just DMT and possibly 5-MeO-DMT!

So as I posted there's probably a Beta-carboline in Black Cohosh, but this seems to me to open a doorway of possible Harmine plus 5-Ho-NMT or NMT containing plant decoctions for new natural ayahuasca-type analogues.

Or at least Harmine + Black Cohosh root extraction might probably enhance the effects.
Now looking into plants with high quantities of clean sources of 5-HO-NMT or NMT.

TiHKAL Norbufotenin entry: http://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5131



Not great at deciphering this page but

Quote
Compound 53 had an elemental composition containing two hydrogens less than 58 and 59 (C12H12N2O), suggesting a dihydro-β-carboline structure. The ready loss of a methyl radical (m/z 186), along with the fragment ion of m/z 170, [MH-CH3NH2]+, indicated that the N(2) nitrogen on the β-carboline ring was methylated. Biosynthetic considerations were used to deduce the position of the double bond on the β-carboline ring. Accordingly, the most likely position of the double bond is 1,2 which was confirmed by comparison of retention time and fragmentation pattern with authentic N(2)-methyl-6-hydroxy-3,4-dihydro-β-carboline. Biosynthetically, this compound is likely formed by dehydrogenation of 58 and represents a new natural product. It should be noted that dihydro-β-carbolines are often by-products of Pictet-Spengler condensation [58]. Thus, it is possible that 58 is an isolation artifact.

Quote
The product ion spectrum of compound 46 eluting at 10.6 min during LC-MS of fraction 4 was dominated by an ion of m/z 144 with the elemental composition (C10H13N2), corresponding to protonated tryptamine. In-source fragmentation followed by MS-MS product ion analysis of m/z 144 showed a fragmentation pattern identical to authentic tryptamine, suggesting that this compound is a tryptamine derivative. The neutral loss of iminoacetic acid (C2H3NO2) combined with database searching suggested that 46 might be a tetrahydro-β-carboline carboxylic acid. Since two positional isomers (1 and 3-substituted) are known, both analogs were synthesized and compared with 46. These experiments identified 46 as 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341503/

Sounds like at least 2 beta-carbolines, possibly
N(2)-methyl-6-hydroxy-3,4-dihydro-β-carboline
1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid

Or similar structures. So the fact that it has beta-carbolines and is used as a classic herbal medicine with really no information or reports on toxicity or overdosing suggests at least some evidence that the compounds in this plant are possibly safe with MAO inhibited?

Also based on that a list of quinoline alkaloids with potential psychoactive effects to research.

salsolinol
norsalsolinol (6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline)
norcoclaurine
reticuline, 6,7-dihydroxy-1-methyl-3,4-dihydroisoquinoline
1,2-dehydrosalsolinol
Aporphine 5-HT1 A and D2 agonist (found in blue lotus)

Quote
Aporphine and its related alkaloids bulbocapnine, boldine, glaucine and corytuberine are antipsychotic, exert naloxone-reversible antinociceptive (reducing sensitivity to painful stimuli) activity and with the exception of corytuberine are anticonvulsant.
https://en.wikipedia.org/wiki/Aporphine

How has no one reported psychoactive effects of this plant beyond a sedative?
This plant has my head spinnin'.

norcoclaurine:
Quote
In a rodent model, it was found that higenamine (norcoclaurine) produced cardiotonic, vascular relaxation, and bronchodilator effects.[8][9] In particular, higenamine, via a beta-adrenoceptor mechanism, induced relaxation in rat corpus cavernosum, leading to improved vasodilation and erectile function.

Related to improved vasodilatory signals, higenamine has been shown in animal models to possess antiplatelet and antithrombotic activity via a cAMP-dependent pathway, suggesting higenamine may contribute to enhanced vasodilation and arterial integrity.[2][7][9][10]
https://en.wikipedia.org/wiki/Higenamine

Quote
Reticuline is one of the alkaloids found in opium, and experiments in rodents suggest it possesses potent central nervous system depressing effects.[3] It is the precursor of morphine and many other alkaloids.
https://en.wikipedia.org/wiki/Reticuline

317
Black Cohosh is a selective estrogen receptor modulator (SERM), found to be non-estrogenic and anti-estrogenic at receptors in the hypothalmus, bone, liver, brain, and arteries primarily.

Synthetic SERMS are usually taken with prohormones and steroids by bodybuilders to minimize effects from excess testosterone being converted to estrogens.

Usually SERMs are estrogenic at some receptors and anti at others and the point is to get the benefits of estrogen and none of the negative effects by blocking the receptors from the free-flowing estrogens in the body. The fact that they bind at estrogen receptor sites still makes them estrogens (they still have estrogenic effects).

Natural black cohosh doesn't. It can be used all the time and to greater effect.

Black cohosh binds at these estrogen receptor sites but doesn't cause any estrogen-like effects and is anti-estrogenic, which would mean it would clean any natural estrogens in your body from effecting you by blocking the receptors. Like those artificial estrogens/hormone disrupters like those that are leached from plastic water bottles.

318
Quote
Constituents: Constituents of black cohosh with proposed or demonstrated pharmacological activity include triterpine glycosides (23-epi-26-deoxyactein, actein, 27-deoxyactein, cimicifugoside A, cimicifugoside M, cimiracemoside A-H)21,45,46,47,48,12,49,50,51, cyclolanostanol xylosides 52, isoflavonone formononetin 53, hydroxytyrosol 54, actaeaeposcide 55, phenylpropanoids (cimiracemate A, cimiracemate B)8,56, organic acids (caffeic acid, cimicifugic acid A, cimicifugic acid B, cimicifugic acid E, cimicifugic acid F, cinnamic acid ester dehydrocimicifugic A, dehydrocimicifugic acid B, dihydroxyphenyl lactic acid, ferulic acid, fukinolic acid, isoferulic acid, methyl caffeate acid, salicylic acid)8,57,54,58, phenols57, quinoid metabolites of caffeic acid, cimiracemate B, fukinolic acid, fukiic acid, and.hydroxytyrosol54. Actaea racemosa specifically contains lignans (e.g., actaealactone), phenylpropanoid ester derivatives (e.g., cimicifugic acid), polyphenols (0.36-2.92% (w/w) in dried root and rhizome), protocatechuic acid, protocatechualdehyde, p-coumaric acid, caffeic acid, methyl caffeate, ferulic acid, ferulate-1-methyl ester, isoferulic acid, 1-isoferuloyl-beta-d-glucopyranoside, fukinolic acid, and cimicifugic acids A, B, and D-F

Quote
Neuropharmacologic effects: Black cohosh has been shown to exhibit an action on the central endogenous opioid system in postmenopausal women as evidenced by suppression of mean luteinizing hormone pulse frequency following opioid receptor blockade.

http://www.sigmaaldrich.com/life-science/nutrition-research/learning-center/plant-profiler/cimicifuga-racemosa.html


Quote
Black cohosh extract showed inhibitory potential for histamine release

It's an anti-histamine (anti-allergenic) but could possibly cause flushing and itching symptoms at higher doses.

Dextromethorphan (DXM) is like that. Is an anti-histamine but causes histamine release at higher doses.

Erowid lists Black Cohosh as a "Mild Sedative; Anti-spasmodic". No reports.



Also reading seeing shit on webmd like:

"Breast cancer: There is some concern that black cohosh might worsen existing breast cancer. Women who have breast cancer or who have had breast cancer in the past, and women at high-risk for breast cancer, should avoid black cohosh."

I'm reading multiple studies about it helps breast cancer in
Herbal Contraindications and Drug Interactions plus Herbal Adjuncts With Medicines
The agenda of the pharmaceutical industry and it's medical community of pushers is strong.



Quote
Black Cohosh behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547488/



Quote
The first medicinal use of black cohosh is generally attributed to Native Americans, who used black cohosh for the treatment of a variety of disorders, including various conditions unique to women such as amenorrhea and menopause, rheumatism, kidney disorders, malaise, and pain during menses and childbirth
Quote
Dr. John King claimed that Macrotys was a remedy of “abnormal conditions of the principal organs of reproduction in the female”, and the roots “very efficacious in the treatment of chronic ovaritis, endometriosis, and menstrual derangements, such as amenorrhea, dysmenorrhea”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547488/

Dopamine receptor activity:
Quote
Dopaminergic activity in the CR extract BNO 1055 could be demonstrated with the D(2)-receptor assay. A countercurrent chromatography resulted in a separation of estrogenic and dopaminergic activity in two distinct fractions.
https://www.ncbi.nlm.nih.gov/pubmed/12609557/

So activity at serotonin, dopamine, and opioid receptors.



5-MeO-DMT, Bufotenin, DMT, LSD, MDA, MDMA, Mescaline, Psilocin are all also 5-HT1 A agonists.

http://www.biopsychiatry.com/psilocybin.htm
http://pharmacologycorner.com/serotonin-5ht-receptors-agonists-antagonist/

Black Cohosh also has affinity at 5-HT1D which LSD also agonizes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684073/

Buspirone (antidepressant) is a 5-HT 7 agonist and is known to cause hallucinations.

http://www.ehealthme.com/ds/buspar/hallucinations
https://treato.com/Buspar,Hallucinations/?a=s

319
Black cohosh contains

Nω-methylserotonin
5-hydroxytryptamine

and other tryptamine analogues

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684073/

"Possible occurrence of a β-carboline pathway in the oxidative catabolism of 5-hydroxytryptamine: chemical approach and structure determination of a yellow substance and related β-carboline derivatives. "
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341503/

and a pubmed article I can't access.
https://www.ncbi.nlm.nih.gov/pubmed/5870459



Ignore information about estrogen effects. It's of no detriment.

It's selective estrogen receptor modulator (SERM) compounds were found to be non-estrogenic and anti-estrogenic at receptors in the hypothalmus, bone, liver, brain, and arteries primarily.

Synthetic SERMS are usually taken with prohormones and steroids by bodybuilders to minimize effects from excess testosterone being converted to estrogens.

Usually SERMs are estrogenic at some receptors and anti at others and the point is to get the benefits of estrogen and none of the negative effects by blocking the receptors from the free-flowing estrogens in the body. The fact that they bind at estrogen receptor sites still makes them estrogens (they still have estrogenic effects).

Natural black cohosh doesn't. It can be used all the time and to greater effect.

Black cohosh binds at these estrogen receptor sites but doesn't cause any estrogen-like effects and is anti-estrogenic, which would mean it would clean any natural estrogens in your body from effecting you by blocking the receptors. Like those artificial estrogens/hormone disrupters like those that are leached from plastic water bottles.



Quote
N-Methylserotonin is found in plants, animals, and fungi. These include the plants, Actaea racemosa (black cohosh)[1] and Zanthoxylum piperitum,[2] the Green and Golden Bell Frog, Litoria aurea,[3] and Amanita mushrooms.[4] The compound binds to several serotonin receptors, including the 5-HT7 and 5-HT1A receptors, with high affinity (IC50 ≤ 2 nM) and selectivity, and displays agonist activity; besides its direct interaction with the serotonin receptors, N-methylserotonin also acts as a selective serotonin reuptake inhibitor.[1]

Quote
United States
N-Methylserotonin is not scheduled at the federal level in the United States,[5] but could be considered an analog (of Bufotenin), in which case, sales or possession intended for human consumption could be prosecuted under the Federal Analog Act.

Florida
N-Methylserotonin is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[6]


Another name for N-Methylserotonin is Norbufotenine! Bufotenin (5-HO-DMT, N,N-dimethylserotonin) is a psychedelic.

320
Introductions / Re: Thrilled to have found you all.
« on: April 29, 2016, 08:30:55 PM »
Thrilled that your thrilled to have found us!

Welcome to the forum, strider! Looking forward to your contributions!

cheers!

321
Experimental Research / Oral use of Sananga / Piri-Piri?
« on: April 27, 2016, 09:42:20 PM »
I'm looking for any info regarding use of oral effects of Sananga and Piri-Piri.
Anyone with experience in this route of administration?

322
Harmine and Other MAOIs / Harmine and Exceptions to Synthetics Rule
« on: April 27, 2016, 09:11:56 PM »
For now talk of naturally derived chemicals in their pure form will be allowed on the forum so long as the pure chemical is legal.

Harmine, harmaline, possibly tetrohydroharmine, and maybe harmalol are vastly superior to rue and caapi tea which cause nausea and confusion.
Pure harmine is on par with traditionally used entheogens like mushrooms and lsd.

323
Experimental Research / Kambo + Lymphagogic Herbs
« on: April 27, 2016, 05:58:15 PM »
We know that Kambo works on the Lymphatic system.
I was thinking of a complementary modality in which herbs which treat the lymph
are taken before kambo.

Deep breathing also gets the lymph moving.

Herbs that treat the lymph system include Cleavers, Poke Root, Marigold, and Blue Flag.

Poke Root

Quote
Poke root is indicated in the treatment of the lymphatic system. Supporting this system is basic in most anti-cancer treatments as well as cleansing programs for a whole range of health problems. As an alterative, Poke root plays a role in helping to maintain the healthy functioning of the lymphatic system. It is especially indicated in mastitis, where it can be used internally and as a poultice. It is also an indicated remedy in the treatment of adenitis.

Changes can be induced in lymphocytes by certain plant mitogens, one of the most important being phytohaemaglutinin (PHA). It is termed a polyclonal T-cell activator because it reacts with the T-cell surface nonspecifically (i.e. not as an antigen) and produces the same series of cellular events as does antigen, locking onto its specific surface receptor. Unlike the situation with antigen stimulation where only a small fraction of the cells are sensitive, PHA transforms a major portion of the T-cells. Additionally, some B-cells are affected although their response appears to be T-cell dependent. The picture is emerging that helper T-cells are preferentially stimulated by PHA> Poke weed activates both T- and B-lymphocytes.

It appears from the above discussion on the effect Poke root has on lymphocytes that its beneficial role in cancer is a legitimate one. It may be surmised as well that a number of other opportunistic infections and diseases, such as Acquired Immune Deficiency Syndrome (AIDS) may also be beneficially treated with Poke root as one of the therapeutic agents. In lymphatic disorders, Poke root is often used in conjunction with Cleavers or Blue Flag.

https://altnature.com/library/pokeroot.htm

Quote
Poke root has a wide range of uses and is very powerful so it is used in 1/4 of the normal doses. Poke root:

is a remedy for the lymphatic system where it promotes lymphatic drainage and circulation. It cleanses, clears toxins and fights infections. It is recommended for breast lumps and cysts and it:
  • relieves lymphatic congestion,
    swollen lymph glands,
    swollen breasts, and
    mastitis.
[/size]

http://www.herb-health-guide.com/poke-root.html

Cleavers

Quote
The primary benefits of cleavers revolve around this herb's ability to tone the lymphatic system. The lymphatic system is responsible for the drainage and cleansing of fluid from cells, tissue, and organs, as well as for part of the body's natural anti-microbial activity, which occurs in the lymphatic glands. Therefore, lymphatic well-being is a foundation for overall well-being. Drinking a cup of cleavers herb tea, blended with marigold or echinacea, is a perfect remedy for swollen glands, tonsillitis, or any other ailment that would benefit from lymphatic drainage support like respiratory infections. Cleavers have also been traditionally used as a lymphatic tonic to alleviate ulcers and tumors, possibly because of the stimulation of fluid drainage.

Cleavers herb tea can be drunk up to three times a day during healing. It blends well with poke root, echinacea, and marigold to tone the lymphatic system

http://www.healthguideinfo.com/herbal-medicine/p58648/

Blue Flag

Maintains and cleanses lymphatic system and reduces fluid retention.


Calendula / Marigold

Reduces lymphatic congestion and swollen lymph glands.

324
General Discussion / New Sections
« on: April 27, 2016, 05:25:19 PM »
Added new sections and renamed and better organized preexisting ones. Check it out, too many changes to list.
Added an entheogens section as well as an experimental research section.

Time to breathe new life into this forum.

Enjoy.

325
Viral Infections / Ginseng: HIV Antiviral
« on: April 22, 2016, 12:24:07 AM »
"Its potential preventive effects are due in part by its enhancement of chemotaxis" (movement of cells in response to chemical stimulus)", phagocytosis" (the ingestion of a smaller cell or cell fragment, a microorganism, or foreign particles)", and increased total lymphocytes and T helper cells when extract G 115 or an aqueous extract is given in 100 mg doses twice daily for 4-8 weeks (PO in human clinical study)."

Herbal Contraindications and Drug Interactions Plus Herbal Adjuncts with Medicines: Expanded fourth Edition
Francis Brinker, N.D.



326
Viral Infections / Ginseng: Herpes Antiviral
« on: April 22, 2016, 12:15:41 AM »
Quote
Ginseng extract also enhanced the natural killer cell function and antibody-dependent cellular cytotoxicity of human peripheral mononuclear cells against herpesvirus infected cells (in vitro).

Herbal Contraindications and Drug Interactions Plus Herbal Adjuncts with Medicines: Expanded fourth Edition
Francis Brinker, N.D.



327
Addiction Rehabilitation / Ashwagandha
« on: April 19, 2016, 01:21:11 PM »

Quote
After 10 days of using 100mg/kg of a commercial root extract, tolerance to morphine analgesia was inhibited, and morphine dependence was blocked (PO in mice study), suggesting that it could be of use in opiate addiction (speculative).

Herbal Contraindications and Drug Interactions Plus Herbal Adjuncts with Medicines: Expanded fourth Edition
Francis Brinker, N.D.

328
Video / Re: TAKIWASI: HOUSE OF HEALING
« on: April 16, 2016, 11:46:18 PM »
Welcome to the forum!  ;D

329
Complementary Modalities / Hot & Cold Therapy
« on: April 16, 2016, 06:17:32 AM »

Cold Water stimulates and hot water relaxes Together, they are like a Hydrostatic Pump, that increases blood flow allowing for healing.

http://healingtools.tripod.com/thn9.html

330
Video / TAKIWASI: HOUSE OF HEALING (Documentary)
« on: April 14, 2016, 09:44:47 PM »
Traditional Amazonian / shamanic medicine documentary. It's quite good.

Thanks to Kambogahuasca for sharing.

https://vimeo.com/146340483


Enjoy.

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