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The Secret World of Plants

https://topdocumentaryfilms.com/secret-world-plants/

The Gary Knoll Show -The Progressive Radio Network
https://www.youtube.com/user/PRNfm/videos

This guy might be the best doctor that's ever lived. A link to subscribe to his radio show.

Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172228

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The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

https://www.ncbi.nlm.nih.gov/pubmed/22445602

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Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice

https://www.ncbi.nlm.nih.gov/pubmed/10197425

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Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.

https://www.ncbi.nlm.nih.gov/pubmed/8117323

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Honokiol targets mitochondria to halt cancer progression and metastasis.

https://www.ncbi.nlm.nih.gov/pubmed/27276215

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University of Alabama at Birmingham found the compound - honokiol - blocked a protein that drives tumor growth in squamous cell head and neck cancers

http://www.medicalnewstoday.com/articles/295962.php

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Honokiol Ameliorates Amyloidosis and Neuroinflammation and Improves Cognitive Impairment in Alzheimer's Disease Transgenic Mice.

https://www.ncbi.nlm.nih.gov/pubmed/29991481

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Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.
https://www.ncbi.nlm.nih.gov/pubmed/24900561

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SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190350

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Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.

https://www.ncbi.nlm.nih.gov/pubmed/18093712

The Reality Of Truth

https://youtu.be/gDG-bOIQUOw

This highly provocative documentary explores the relationship between spirituality, religion, and plant medicine. Featuring top thought leaders including Deepak Chopra, Ram Dass, Marianne Williamson, Sri Sri Ravi Shankar, and hosted by Mike “Zappy” Zapolin, the film explores how to access the true reality through plant medicine, Ayahuasca and meditation.  It includes first of its kind interviews with top spiritual gurus, celebrities, and people of all faiths, about this intriguing connection and their personal experiences with spirituality and transcendence.

Throughout history human beings have searched for gateways to spirituality that have included meditation, prayer and plant medicine. The Judeo Christian religions, Vedic traditions, and Shamanistic rituals all incorporate techniques focused on transcending the physical reality. These ancient techniques have been uncovered and are now available to society, enabling our ability to tap into our true reality and awakening.

Interviews with leading scientists validate the merging of spirituality and science.

The worldwide awareness of the film is meant to break through the “illusion of reality,” and allow viewers to move forward toward a more meaningful and peaceful future. The filmmakers are conducting interviews with today’s thought leaders from around the globe, while capturing the culture and energy of some of the most spiritual places on earth, including Peru, Rome, Maui, Costa Rica and the Maharishi University of Management in Fairfield, Iowa.

https://www.kratomscience.com/forums/topic/list-alkaloids-identified-mitragyna-speciosa-kratom/

Kratom's constituents and their properties

Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa– Kratom leaf. Some of the alkaloids given in this list still need to be studied more specifically in order to determine their potential activity.

Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.

Akuammigine

Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.

Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.

Corynoxeine: Calcium channel blocker. < 1% of total alkaloid content found in Kratom leaf.

Corynoxine A and B: Dopamine mediating anti-locomotives. < 1% of total alkaloid content found in Kratom leaf.

Epicatechin: Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral, potential cancer preventative, alpha-amylase inhibitor. Also found in dark chocolate.

9-Hydroxycorynantheidine: Partial opioid agonist

7-hydroxymitragynine: Analgesic, antitussive, antidiarrheal; primary
psychoactive in Kratom, Roughly 2% of total alkaloid content found in Kratom leaf.

Isomitraphylline: Immunostimulant, anti-leukemic. < 1% of total alkaloid content found in Kratom leaf.

Isomitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Isopteropodine: Immunostimulant

Isorhynchophylline: Immunostimulant. < 1% of total alkaloid content found in Kratom leaf.

Isospeciofoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraciliatine: < 1% of total alkaloid content found in Kratom leaf.

Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist. Roughly 66% of total alkaloid content found in Kratom leaf.

Mitragynine oxindole B. < 1% of total alkaloid content found in Kratom leaf.

Mitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. <1% of total alkaloid contents in Kratom leaf.

Mitraversine

Paynantheine: Indole alkaloid. Smooth muscle relaxer. 8.6% to 9% of total alkaloid contents in Kratom leaf.

Rhynchophylline: Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic. < 1% of total alkaloid content found in Kratom leaf.

Speciociliatine: Weak opioid agonist. 0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom.

Speciofoline

Speciogynine: Smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of Kratom leaf.

Speciophylline: Indole alkaloid. Anti-leukemic. <1% of total alkaloid contents of Kratom leaf.

Stipulatine

Tetrahydroalstonine: Hypoglycemic, anti-adrenergic (at alpha-2)

As previously mentioned, Mitragyna speciosa Kratom alkaloid content varies quantitatively from geographical location, and from month to month, at different leaf harvest times, which has lead some teams (Shellard et al. in the 1970s) to conclude that there may be different geographical variants within the same species.
The Chelsea College Pharmacognosy Research Laboratories collected thirty samples of Kratom from Thailand, Malaysia, and Papua New Guinea between 1961 and 1970. All contained mitragynine, but also proved to have considerable variation in the alkaloid makeup. For red and green/ white leaved plants of Thailand, the most common alkaloidal profile was mitragynine, speciogynine, speciociliatine, paynantheine, traces of ajmalicine, traces of (C9) methoxy-oxindoles, and traces of other indoles.
Yet other Thai plants contained distinct alkaloidal profiles, some with many more alkaloids. In the Malay specimens, one contained mitragynine, speciofoline, and other indoles and oxindoles, while others contained mitragynine, ajmalicine, speciogynine, speciociliatine, paynantheine, traces of indoles, and (C9) methoxy-oxindoles. Specimens from Papua New Guinea contained mitragynine, speciogynine, speciociliatine, paynantheine, specionoxeine, and isospecionoxeine.
Prior to the late 1990’s, nearly all chemical studies of Kratom activity focused on mitragynine with the assumption thatmitragynine was the main active alkaloid. With 7-hydroxymitragynine now clearly identified out as the principal psychoactive alkaloid in Kratom, many elements of these studies need to be revised.

Takayama et al. also found that Thai and Malay Kratom had the alkaloids mitragynine, speciogynine, speciociliatine, paynantheine and 7-hydroxymitragynine in common. In both Thai and Malay samples, mitragynine was the most abundant alkaloid, yet it made up 66% of the total alkaloid in the Thai Kratom sample, while it made up only 12% of the alkaloids from the Malaysian sample. The Malay Kratom sample had mitragynaline and pinoresinol as major components, as well asmitralactonal, mitrasulgynine and 3,4,5,6-tetradehydromitragynine.
Working with the leaves of Malay Mitragyna Kratom plants, the Houghton and Said team found 4 new types of indole alkaloids (corynantheidaline, corynantheidalinic acid, mitragynaline and mitragynalinic acid), in very young leaves.
These new alkaloids were reported as having an unusual skeleton, with a carbon function at the C14 position (in comparison with previously known monoterpenoid indoles), but another research team, lead by Pr. Takayama, later revised the structure of the mitragynaline and corynantheidaline alkaloids, showing that there was actually no substitution on the 14 position.

The variety of alkaloids discovered in diverse Kratom samples to this day still calls for further studies and experimentation, investigating their specific activity, effects and potential applications.
Through its makeup and tradition of use, it is clear Mitragyna speciosaKratom is much more than a simple opioid-like narcotic and mild stimulant. Many of the secondary chemicals found in Mitragyna speciosa Kratom are present in small yet appreciable quantities, and their synergetic role and activity in the general pharmacology of Mitragyna speciosa Kratom is not yet fully understood, as thorough research has only just begun.