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Classes of Plant Constituents => Alkaloidology => Topic started by: ―λlτεrηιτγ- on August 14, 2018, 05:01:49 AM

Title: Honokiol & Magnolol from Magnolia
Post by: ―λlτεrηιτγ- on August 14, 2018, 05:01:49 AM
Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172228 (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172228)

The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

https://www.ncbi.nlm.nih.gov/pubmed/22445602 (https://www.ncbi.nlm.nih.gov/pubmed/22445602)

Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice

https://www.ncbi.nlm.nih.gov/pubmed/10197425 (https://www.ncbi.nlm.nih.gov/pubmed/10197425)

Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.

https://www.ncbi.nlm.nih.gov/pubmed/8117323 (https://www.ncbi.nlm.nih.gov/pubmed/8117323)

Honokiol targets mitochondria to halt cancer progression and metastasis.

https://www.ncbi.nlm.nih.gov/pubmed/27276215 (https://www.ncbi.nlm.nih.gov/pubmed/27276215)

University of Alabama at Birmingham found the compound - honokiol - blocked a protein that drives tumor growth in squamous cell head and neck cancers

http://www.medicalnewstoday.com/articles/295962.php (http://www.medicalnewstoday.com/articles/295962.php)

Honokiol Ameliorates Amyloidosis and Neuroinflammation and Improves Cognitive Impairment in Alzheimer's Disease Transgenic Mice.

https://www.ncbi.nlm.nih.gov/pubmed/29991481 (https://www.ncbi.nlm.nih.gov/pubmed/29991481)

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.
https://www.ncbi.nlm.nih.gov/pubmed/24900561 (https://www.ncbi.nlm.nih.gov/pubmed/24900561)

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190350 (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190350)

Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.

https://www.ncbi.nlm.nih.gov/pubmed/18093712 (https://www.ncbi.nlm.nih.gov/pubmed/18093712)